Delaviz Yasaman, Yang Meilin, Santerre J Paul
Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON M5G 1M1, Canada.
Faculty of Dentistry, University of Toronto, Toronto, ON M5G 1G6, Canada.
Polymers (Basel). 2017 Aug 17;9(8):365. doi: 10.3390/polym9080365.
The monomeric components of resin composites in dental restorative materials are susceptible to hydrolysis in the oral cavity. The main objective of this study was to assess the bio-stability of fluorinated urethane dimethacrylates and determine the nature of fluoro-chemistry interactions with protein and bacterial adhesion (both sources of hydrolytic activity) onto cured resin. Degradation studies were performed in the presence of either albumin (in a mildly alkaline pH) or cholesterol esterase (CE). The surface chemistry of the polymers was assessed by water contact angle measurements, pre- and post- incubation with albumin. Adhesion of to cured resin was investigated. The fluorinated monomers were more stable against degradation when compared to the commercial monomer bisphenol A-diglycidyl methacrylate (BisGMA). While fluorinated monomers showed hydrolytic stability with respect to CE, all fluorinated monomers underwent some degree of degradation with albumin. The fluoro-chemistry did not reduce protein and/or bacterial adhesion onto the surface, however post incubation with albumin, the fluorinated surfaces still presented hydrophobic character as determined by the high contact angle values ranging from 79° to 86°. These monomers could potentially be used to increase the hydrophobicity of polymeric composites and provide a means to moderate esterolytic degradation associated with the monomeric component of the polymers within the oral cavity.
牙科修复材料中树脂复合材料的单体成分在口腔中易发生水解。本研究的主要目的是评估含氟聚氨酯二甲基丙烯酸酯的生物稳定性，并确定氟化学与蛋白质和细菌粘附（水解活性的两种来源）在固化树脂上的相互作用性质。在白蛋白（在微碱性pH值下）或胆固醇酯酶（CE）存在的情况下进行降解研究。通过水接触角测量以及与白蛋白孵育前后评估聚合物的表面化学。研究了细菌对固化树脂的粘附情况。与市售单体双酚A - 二缩水甘油甲基丙烯酸酯（BisGMA）相比，含氟单体对降解更稳定。虽然含氟单体对CE表现出水解稳定性，但所有含氟单体与白蛋白一起时都经历了一定程度的降解。氟化学并没有降低蛋白质和/或细菌在表面的粘附，然而与白蛋白孵育后，通过79°至86°的高接触角值确定，含氟表面仍呈现疏水性。这些单体有可能用于增加聚合物复合材料的疏水性，并提供一种手段来缓和与口腔内聚合物单体成分相关的酯解降解。
