Giuliani SpA, Milan, Italy.
Human Advanced Microbiome Project-HMAP, Milan, Italy.
PLoS One. 2019 Apr 11;14(4):e0215206. doi: 10.1371/journal.pone.0215206. eCollection 2019.
The role of microbial dysbiosis in scalp disease has been recently hypothesized. However, little information is available with regards to the association between microbial population on the scalp and hair diseases related to hair growth. Here we investigated bacterial communities in healthy and Alopecia areata (AA) subjects. The analysis of bacterial distribution at the genus level highlighted an increase of Propionibacterium in AA subjects alongside a general decrease of Staphylococcus. Analysis of log Relative abundance of main bacterial species inhabiting the scalp showed a significant increase of Propionibacterium acnes in AA subjects compared to control ones. AA scalp condition is also associated with a significant decrease of Staphylococcus epidermidis relative abundance. No significant changes were found for Staphylococcus aureus. Therefore, data from sequencing profiling of the bacterial population strongly support a different microbial composition of the different area surrounded hair follicle from the epidermis to hypodermis, highlighting differences between normal and AA affected the scalp. Our results highlight, for the first time, the presence of a microbial shift on the scalp of patients suffering from AA and gives the basis for a larger and more complete study of microbial population involvement in hair disorders.
微生物失调在头皮疾病中的作用最近被假设。然而，关于头皮微生物群与毛发生长相关的头发疾病之间的关联，信息很少。在这里，我们研究了健康和斑秃（AA）受试者的细菌群落。在属水平上分析细菌分布，突出了 AA 受试者丙酸杆菌的增加，同时葡萄球菌的普遍减少。对栖息在头皮上的主要细菌物种的对数相对丰度的分析表明，AA 受试者的痤疮丙酸杆菌显著增加，而对照受试者则没有。AA 头皮状况也与表皮葡萄球菌相对丰度的显著降低有关。金黄色葡萄球菌没有发现明显变化。因此，细菌种群测序分析的结果强烈支持从表皮到皮下组织围绕毛囊的不同区域的微生物组成不同，突出了正常和 AA 受影响头皮之间的差异。我们的研究结果首次强调了 AA 患者头皮上存在微生物转移，并为进一步研究微生物群在毛发疾病中的作用提供了基础。
