Bärenwald Ruth, Achilles Anja, Lange Frank, Ferreira Tiago Mendes, Saalwächter Kay
Institut für Physik-NMR, Martin-Luther-Universität Halle-Wittenberg, D-06120 Halle, Germany.
Polymers (Basel). 2016 Dec 16;8(12):439. doi: 10.3390/polym8120439.
The incorporation of polymers or smaller complex molecules into lipid membranes allows for property modifications or the introduction of new functional elements. The corresponding molecular-scale details, such as changes in dynamics or features of potential supramolecular structures, can be studied by a variety of solid-state NMR techniques. Here, we review various approaches to characterizing the structure and dynamics of the guest molecules as well as the lipid phase structure and dynamics by different high-resolution magic-angle spinning proton and C NMR experiments as well as static P NMR experiments. Special emphasis is placed upon the incorporation of novel synthetic polyphilic molecules such as shape-persistent T- and X-shaped molecules as well as di- and tri-block copolymers. Most of the systems studied feature dynamic heterogeneities, for instance those arising from the coexistence of different phases; possibilities for a quantitative assessment are of particular concern.
将聚合物或较小的复杂分子掺入脂质膜中可实现性质修饰或引入新的功能元素。相应的分子尺度细节，如动力学变化或潜在超分子结构的特征，可通过多种固态核磁共振技术进行研究。在此，我们回顾了通过不同的高分辨率魔角旋转质子和碳核磁共振实验以及静态磷核磁共振实验来表征客体分子的结构和动力学以及脂质相结构和动力学的各种方法。特别强调了新型合成双亲分子的掺入，如形状持久的T形和X形分子以及二嵌段和三嵌段共聚物。大多数研究的体系具有动态不均匀性，例如由不同相共存引起的那些；定量评估的可能性尤为重要。
