Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China.
Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
Molecules. 2019 Apr 10;24(7):1405. doi: 10.3390/molecules24071405.
Seven resorcylic acid lactones (RALs) including five new analog rhinoclactones, A-E (, , -), were isolated from an endophytic fungus in the plant collected from the Tengger Desert of the Ningxia Province, China. The structures of these new compounds were determined by HR-ESI-MS (High Resolution Electrospray Ionization Mass Spectrometry), NMR data, modified Mosher's method, and X-ray diffraction experiments. All compounds isolated from this fungus possessed the 16-OMe/14-OH, not the common 16-OH/14-OH or 16-OH/14-OMe groups on the aromatic ring, which are rarely found in nature. Compound displayed cytotoxic activities against HCT116 and HeLa cancer cell lines. The possible biosynthesis of - is suggested, and the potential ecological roles of these fungal secondary metabolites is discussed.
从中国宁夏腾格里沙漠植物内生真菌中分离得到了七种雷锁辛内酯（RALs），包括五个新的类似物 rhinoclactones A-E（、、-）。这些新化合物的结构通过高分辨电喷雾电离质谱（HR-ESI-MS）、NMR 数据、改良的 Mosher 法和 X 射线衍射实验确定。从这种真菌中分离得到的所有化合物都具有 16-OMe/14-OH，而不是常见的 16-OH/14-OH 或 16-OH/14-OMe 基团，这在自然界中很少见。化合物对 HCT116 和 HeLa 癌细胞系表现出细胞毒性活性。提出了-的可能生物合成途径，并讨论了这些真菌次生代谢物的潜在生态作用。
