Institute of Medicinal Plant Development , Peking Union Medical College and Chinese Academy of Medical Sciences , Beijing 100193 , People's Republic of China.
College of Pharmacy , Qiqihar Medical University , Qiqihar 161006 , Heilongjiang , People's Republic of China.
Org Lett. 2019 Apr 5;21(7):2139-2142. doi: 10.1021/acs.orglett.9b00454. Epub 2019 Mar 11.
Trematosphones A (1) and B (2), two unique dimers with novel structural features, were isolated from the special bioenvironmental desert plant endophytic fungus Trematosphaeria terricola. Their structures were assigned on the basis of spectroscopic approaches including NMR, calculated electronic circular dichroism data, and X-ray diffraction analysis. Possible biosynthetic pathways of these two compounds were proposed. Trematosphone A (1) exhibited protective activities against the corticosterone-induced damages in PC12.
从特殊生物环境沙漠植物内生真菌嗜热腔菌（Trematosphaeria terricola）中分离得到了 Trematosphones A（1）和 B（2），这两种独特的二聚体具有新颖的结构特征。基于包括 NMR、计算电子圆二色性数据和 X 射线衍射分析在内的光谱方法确定了它们的结构。提出了这两种化合物的可能生物合成途径。 Trematosphone A（1）对皮质酮诱导的 PC12 损伤具有保护作用。
