Department of Nutrition and Food Science, Complutense University of Madrid, 28040 Madrid, Spain.
Department of Galenic Pharmacy and Food Technology, Complutense University of Madrid, 28040 Madrid, Spain.
Nutrients. 2019 Apr 10;11(4):810. doi: 10.3390/nu11040810.
(Group B Streptococci, GBS) can cause severe neonatal sepsis. The recto-vaginal GBS screening of pregnant women and intrapartum antibiotic prophylaxis (IAP) to positive ones is one of the main preventive options. However, such a strategy has some limitations and there is a need for alternative approaches. Initially, the vaginal microbiota of 30 non-pregnant and 24 pregnant women, including the assessment of GBS colonization, was studied. Among the isolates, 10 strains were selected for further characterization. In vitro characterization revealed that CECT 9145 was the best candidate for GBS eradication. Its efficacy to eradicate GBS from the intestinal and vaginal tracts of pregnant women was evaluated in a pilot trial involving 57 healthy pregnant women. All the volunteers in the probiotic group ( = 25) were GBS-positive and consumed ~9 log cfu of CECT 9145 daily from week 26 to week 38. At the end of the trial (week 38), 72% and 68% of the women in this group were GBS-negative in the rectal and vaginal samples, respectively. CECT 9145 seems to be an efficient method to reduce the number of GBS-positive women during pregnancy, decreasing the number of women receiving IAP during delivery.
（B 组链球菌，GBS）可导致严重的新生儿败血症。对孕妇进行直肠阴道 GBS 筛查，并对阳性者进行产时抗生素预防（IAP），是主要的预防措施之一。然而，这种策略存在一些局限性，需要寻找替代方法。最初，研究了 30 名非孕妇和 24 名孕妇的阴道微生物群，包括 GBS 定植的评估。在分离的菌株中，选择了 10 株进行进一步的特征分析。体外特征分析表明，CECT 9145 是消除 GBS 的最佳候选菌株。在一项涉及 57 名健康孕妇的试点试验中，评估了 CECT 9145 从孕妇肠道和阴道中消除 GBS 的效果。益生菌组的所有志愿者（n=25）均为 GBS 阳性，从 26 周到 38 周，每天摄入约 9 对数 CFU 的 CECT 9145。试验结束时（第 38 周），该组中有 72%和 68%的女性直肠和阴道样本中 GBS 呈阴性。CECT 9145 似乎是一种有效的方法，可以减少怀孕期间 GBS 阳性女性的数量，减少分娩时接受 IAP 的女性数量。
