Department of Nutrition and Food Science, Complutense University of Madrid, 28040 Madrid, Spain.
Centro de Salud Bermeo, Tonpoi Kalea, s/n, 48370 Bermeo, Bizkaia, Spain.
Nutrients. 2019 Feb 12;11(2):376. doi: 10.3390/nu11020376.
Acute otitis media (AOM) is one of the most common bacterial infections in children. Empiric antibiotherapy leads to increasing antimicrobial resistance rates among otopathogens and may impair the correct development of the microbiota in early life. In this context, probiotics seem to be an attractive approach for preventing recurrent AOM (rAOM) through the restoration of the middle ear and nasopharyngeal microbiota. The aim of this study was the selection of a probiotic strain ( PS7), specifically tailored for its antagonism against otopathogens. Since PS7 was safe and displayed a strong antimicrobial activity against otopathogens, its efficacy in preventing rAOM was assessed in a trial involving 61 children suffering from rAOM. Children consumed daily ~1 × 10⁸ CFU of PS7, and the number of AOM episodes were registered and compared with that observed in the previous 6 and 12 months. The microbiota of samples collected from the external auditory canal samples was quantitatively and qualitatively assessed. The number of AOM episodes during the intervention period decreased significantly (84%) when compared to that reported during the 6 months period before the probiotic intervention. In conclusion, PS7 is a promising strain for the prevention of rAOM in infants and children.
急性中耳炎（AOM）是儿童最常见的细菌感染之一。经验性抗生素治疗导致耳病原体的抗微生物药物耐药率不断上升，并可能损害生命早期微生物组的正确发育。在这种情况下，益生菌似乎是通过恢复中耳和鼻咽微生物组来预防复发性 AOM（rAOM）的一种有吸引力的方法。本研究的目的是选择一种益生菌菌株（PS7），专门针对其对抗耳病原体的拮抗作用。由于 PS7 安全且对耳病原体具有很强的抗菌活性，因此在一项涉及 61 名患有 rAOM 的儿童的试验中评估了其预防 rAOM 的功效。儿童每天消耗约 1×10⁸ CFU 的 PS7，记录 AOM 发作次数，并与前 6 个月和 12 个月观察到的次数进行比较。从外耳道样本中采集的样本的微生物组进行了定量和定性评估。与益生菌干预前 6 个月报告的 AOM 发作次数相比，干预期间的 AOM 发作次数显著减少（84%）。总之，PS7 是预防婴儿和儿童 rAOM 的有前途的菌株。
