催化在选择性蛋白质修饰中的概念。

Chemistry Research Laboratory, Department of Chemistry , University of Oxford , Mansfield Road , Oxford OX1 3TA , United Kingdom.

J Am Chem Soc. 2019 May 22;141(20):8005-8013. doi: 10.1021/jacs.8b13187. Epub 2019 Apr 25.

The manipulation and modulation of biomolecules has the potential to herald new modes of Biology and Medicine through chemical "editing". Key to the success of such processes will be the selectivities, reactivities and efficiencies that may be brought to bear in bond-formation and bond-cleavage in a benign manner. In this Perspective, we use select examples, primarily from our own research, to examine the current opportunities, limitations and the particular potential of metal-mediated processes as exemplars of possible alternative catalytic modes and manifolds to those already found in nature.

生物分子的操纵和调节有可能通过化学“编辑”开创生物学和医学的新模式。这些过程的成功关键将是选择性、反应性和效率，可以以良性的方式应用于键的形成和断裂。在本观点中，我们主要使用我们自己的研究中的一些示例，来考察当前的机会、限制以及金属介导过程的特殊潜力，这些过程是可能替代自然中已经存在的催化模式和流形的范例。