Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Division of Endocrinology, Department of Internal Medicine, National Health Insurance Service Ilsan Hospital, Goyang, Korea.
Geriatr Gerontol Int. 2017 Jul;17(7):1069-1075. doi: 10.1111/ggi.12826. Epub 2016 Jul 22.
Metabolic syndrome and vitamin D deficiency are prevalent in older adults, and are considered risk factors for cognitive impairment. We investigated the combined effects of MetS and serum 25-hydroxyvitamin D (25[OH]D) levels on cognitive function in older adults.
We studied 2940 participants aged ≥65 years from the Korean Urban Rural Elderly cohort study. Metabolic syndrome was defined according to the updated Adult Treatment Panel III criteria. Serum 25(OH)D levels were categorized into four groups: <25, 25-49, 50-74 and ≥75 nmol/L. Cognitive function was assessed using the Mini-Mental State Examination.
Participants with cognitive impairment had higher metabolic syndrome prevalence and lower serum 25(OH)D levels than those without cognitive impairment. In univariate analysis, both metabolic syndrome and low 25(OH)D levels were associated with cognitive impairment. These associations remained unchanged after adjusting for potential confounders including age, sex, season and education. In addition, participants with metabolic syndrome and low 25(OH)D had significantly increased odds for cognitive impairment (odds ratio 3.06, 95% CI 1.61-5.80) when compared with those with no metabolic syndrome and high 25(OH)D.
Metabolic syndrome was associated with cognitive impairment, and this risk was synergistically increased when metabolic syndrome was combined with low 25(OH)D. A focus on individuals with metabolic syndrome and low 25(OH)D might be helpful to identify older adults who are at risk of cognitive impairment. Geriatr Gerontol Int 2017; 17: 1069-1075.
代谢综合征和维生素 D 缺乏在老年人中很常见，被认为是认知障碍的危险因素。我们研究了代谢综合征和血清 25-羟维生素 D（25[OH]D）水平对老年人认知功能的综合影响。
我们研究了来自韩国城乡老年队列研究的 2940 名年龄≥65 岁的参与者。代谢综合征根据最新的成人治疗小组 III 标准定义。血清 25(OH)D 水平分为四组：<25、25-49、50-74 和≥75 nmol/L。认知功能采用简易精神状态检查进行评估。
认知障碍患者的代谢综合征患病率较高，血清 25(OH)D 水平较低。在单因素分析中，代谢综合征和低 25(OH)D 水平均与认知障碍有关。这些关联在调整了包括年龄、性别、季节和教育等潜在混杂因素后仍然不变。此外，与无代谢综合征和高 25(OH)D 相比，代谢综合征和低 25(OH)D 的患者认知障碍的几率显著增加（比值比 3.06，95%CI 1.61-5.80）。
代谢综合征与认知障碍有关，当代谢综合征与低 25(OH)D 结合时，这种风险会协同增加。关注患有代谢综合征和低 25(OH)D 的个体可能有助于识别有认知障碍风险的老年人。老年医学与老年病学国际 2017; 17: 1069-1075。
