Lee Jinsoo, Jeong Ji-Seong, Cho Kyung-Jin, Moon Kyeong-Nang, Kim Sang Yun, Han Byungcheol, Kim Yong-Soon, Jeong Eun Ju, Chung Moon-Koo, Yu Wook-Joon
Developmental and Reproductive Toxicology Research Group, Korea Institute of Toxicology, Daejeon, Republic of Korea.
Fundamental Laboratory, R&D Headquarters, Korea Ginseng Corp., Daejeon, Republic of Korea.
J Ginseng Res. 2019 Apr;43(2):242-251. doi: 10.1016/j.jgr.2017.12.004. Epub 2018 Jan 10.
Korean Red Ginseng has been widely used in traditional oriental medicine for a prolonged period, and its pharmacological effects have been extensively investigated. In addition, and were also used as a tonic medicine with Korean Red Ginseng as the oriental herbal therapy.
This study was conducted to evaluate the potential toxicological effect of KGC-HJ3, Korean Red Ginseng with and , on reproductive and developmental functions including fertility, early embryonic development, maternal function, and embryo-fetal development. KGC-HJ3 was administered by oral gavage to Sprague-Dawley rats (22 animals per sex per group) at dose levels of 0 mg/kg (control), 500 mg/kg, 1000 mg/kg, and 2000 mg/kg to evaluate the potential toxicological effect on fertility and early embryonic development. In addition, KGC-HJ3 was also administered by oral gavage to mating-proven Sprague-Dawley rats (22 females per group) during the major organogenesis period at dose levels of 0 mg/kg (control), 500 mg/kg, 1000 mg/kg, and 2000 mg/kg to evaluate the potential toxicological effect on maternal function and embryo-fetal development.
No test item-related changes in parameters for fertility, early embryonic development, maternal function, and embryo-fetal development were observed during the study period. On the basis of these results, it was concluded that KGC-HJ3 did not have toxicological potential on developmental and reproductive functions. Therefore, no observed adverse effect levels of KGC-HJ3 for fertility, early embryonic development, maternal function, and embryo-fetal development is considered to be at least 2000 mg/kg/day.
高丽参在传统东方医学中已被广泛使用了很长时间，并且对其药理作用进行了广泛研究。此外，[此处原文缺失两种物质名称]也与高丽参一起被用作东方草药疗法的滋补药。
本研究旨在评估KGC-HJ3（高丽参与[此处原文缺失两种物质名称]）对生殖和发育功能（包括生育力、早期胚胎发育、母体功能和胚胎-胎儿发育）的潜在毒理学影响。通过灌胃法将KGC-HJ3以0 mg/kg（对照）、500 mg/kg、1000 mg/kg和2000 mg/kg的剂量水平给予Sprague-Dawley大鼠（每组每种性别22只动物），以评估其对生育力和早期胚胎发育的潜在毒理学影响。此外，在主要器官形成期，通过灌胃法将KGC-HJ3以0 mg/kg（对照）、500 mg/kg、1000 mg/kg和2000 mg/kg的剂量水平给予经交配验证的Sprague-Dawley大鼠（每组22只雌性），以评估其对母体功能和胚胎-胎儿发育的潜在毒理学影响。
在研究期间，未观察到与受试物相关的生育力、早期胚胎发育、母体功能和胚胎-胎儿发育参数的变化。基于这些结果，得出结论：KGC-HJ3对发育和生殖功能没有毒理学潜力。因此，KGC-HJ3对生育力、早期胚胎发育、母体功能和胚胎-胎儿发育的未观察到有害作用水平被认为至少为2000 mg/kg/天。
