Zheng Wei, Zhu Wen-Wei, Feng Zhi-Chao, Liang Qi, Rong Peng-Fei, Li Li-Feng, Liao Yun-Jie, Wang Wei
Department of Radiology, The Third Xiangya Hospital, Central South University, Changsha 410013, China.
Quant Imaging Med Surg. 2019 Feb;9(2):230-237. doi: 10.21037/qims.2018.12.12.
Grey matter volume (GMV) loss has been observed in patients with non-alcoholic cirrhosis, but the underlying mechanisms are unknown. Oxidative stress (OS) is a recognized feature and systemic phenomenon of cirrhosis. However, little is known about whether OS is associated with GMV loss in cirrhosis. This study aimed to assess the relationship between oxidative damage and GMV loss in patients with non-alcoholic cirrhosis.
Thirty-four patients with non-alcoholic cirrhosis and 27 age- and sex-matched healthy controls were enrolled in this prospective study. All subjects underwent brain magnetic resonance imaging (MRI), and voxel-based morphometry (VBM) was performed to assess normalized global GMV. As an OS marker, serum malondialdehyde (MDA) levels were determined in all subjects. In the patient group, a correlation analysis was used to investigate the relationship between serum MDA levels and normalized global GMV.
Compared with healthy controls, cirrhotic patients displayed a significant decrease in normalized global GMV and a significant increase in serum MDA levels. In the patient group, serum MDA levels were negatively correlated with normalized global GMV adjusted for age, sex and Child-Pugh class.
Increased serum MDA levels were associated with GMV loss in patients with non-alcoholic cirrhosis, suggesting that oxidative damage may be involved in GMV loss observed in cirrhotic patients.
非酒精性肝硬化患者存在灰质体积（GMV）损失，但潜在机制尚不清楚。氧化应激（OS）是肝硬化公认的特征和全身性现象。然而，关于OS是否与肝硬化患者的GMV损失相关，知之甚少。本研究旨在评估非酒精性肝硬化患者氧化损伤与GMV损失之间的关系。
本前瞻性研究纳入了34例非酒精性肝硬化患者和27例年龄及性别匹配的健康对照者。所有受试者均接受脑磁共振成像（MRI）检查，并采用基于体素的形态学测量（VBM）来评估标准化的全脑GMV。测定所有受试者血清丙二醛（MDA）水平作为OS标志物。在患者组中，采用相关性分析来研究血清MDA水平与标准化全脑GMV之间的关系。
与健康对照者相比，肝硬化患者标准化全脑GMV显著降低，血清MDA水平显著升高。在患者组中，经年龄、性别和Child-Pugh分级校正后，血清MDA水平与标准化全脑GMV呈负相关。
血清MDA水平升高与非酒精性肝硬化患者的GMV损失相关，提示氧化损伤可能参与了肝硬化患者中观察到的GMV损失。
