University of Miami Miller School of Medicine and Miami Veterans Affairs Healthcare System, Miami, FL 33125.
Microbiol Spectr. 2019 Mar;7(2). doi: 10.1128/microbiolspec.GPP3-0016-2018.
Streptococci carrying serogroup C and G antigens, and in particular, subsp. (SDSE), are emerging human pathogens that are increasingly isolated from patients with a myriad of infections that range from mundane to life-threatening. SDSE is microbiologically similar to . These streptococci frequently cause infections of the throat and skin and soft tissues. Moreover, they may invade the bloodstream and disseminate widely to many deep tissue sites, including the endocardium. Life-threatening invasive infections due to SDSE, including the streptococcal toxic shock syndrome, occur most frequently in patients with severe underlying medical diseases. Treatment with penicillin is adequate under most circumstances, but treatment failure occurs. SDSE may also be resistant to other antibiotic classes including tetracyclines, macrolides, and clindamycin. Most human infections caused by groups C and G streptococci are transmitted from person to person, but infections due to subsp. (and, rarely, to subsp. ) are zoonoses. Transmission of these latter species occurs by animal contact or by contamination of food products and has been associated with the development of poststreptococcal glomerulonephritis. Members of the group, usually classified with the viridans group of streptococci, are associated with a variety of pyogenic infections.
携带 C 群和 G 群抗原的链球菌，特别是亚群（SDSE），是新兴的人类病原体，越来越多地从患有各种感染的患者中分离出来，这些感染从平凡到危及生命不等。SDSE 在微生物学上与相似。这些链球菌经常引起喉咙和皮肤及软组织感染。此外，它们可能侵入血液并广泛传播到许多深部组织部位，包括心内膜。由于 SDSE 引起的危及生命的侵袭性感染，包括链球菌中毒性休克综合征，最常发生在患有严重基础医学疾病的患者中。在大多数情况下，青霉素治疗是足够的，但治疗失败会发生。SDSE 也可能对其他抗生素类别（包括四环素、大环内酯类和克林霉素）产生耐药性。大多数由 C 群和 G 群链球菌引起的人类感染是人与人之间传播的，但由于亚群（和很少由亚群）引起的感染是动物源性疾病。这些后一种物种的传播是通过动物接触或食品污染引起的，与链球菌后肾小球肾炎的发展有关。组的成员通常与草绿色链球菌群分类在一起，与各种化脓性感染有关。
