Medical School, Federal University of Fronteira Sul, Rodovia SC 484-Km 02, Fronteira Sul, Chapecó, SC, 89815-899, Brazil.
Graduate Program in Biomedical Sciences, Medicine Course, Federal University of Fronteira Sul, Fronteira Sul, Campus Chapecó, Rodovia SC 484-Km 02, Chapecó, SC, 89815-899, Brazil.
Inflamm Res. 2022 Jun;71(5-6):555-564. doi: 10.1007/s00011-022-01560-8. Epub 2022 Apr 4.
Cervical cancer is the fourth most prevalent type of cancer in the world. The tumor microenvironment of this disease is associated with the production of several cytokines, pro and anti-inflammatory, and with the purinergic signaling system so that changes in these components are observed throughout the pathological process. The aim of this review is to understand the pathophysiology of cervical cancer based on immunological processes and purinergic signaling pathways, in addition to suggesting possibilities of therapeutic targets.
To make up this review, studies covering topics of cervical cancer, inflammation and purinergic system were selected from the Pubmed.
The main pro-inflammatory cytokines involved are IL-17, IL-1β, IL-6, and IL-18, and among the anti-inflammatory ones, IL-10 and TGF-β stand out. As new therapeutic targets, P2X7 and A2A receptors have been suggested, since blocking P2X7 would lead to reduced release of pro-inflammatory cytokines, and blocking A2A would increase activation of cytotoxic T lymphocytes in the context of tumor combat. The association between the immune system and the purinergic system, already known in other types of disease, also presents possibilities for a better understanding of biomolecular processes and therapeutic possibilities in the context of cervical cancer.
宫颈癌是世界上第四种最常见的癌症。这种疾病的肿瘤微环境与几种细胞因子的产生有关，包括促炎和抗炎细胞因子，以及嘌呤能信号系统，因此在整个病理过程中观察到这些成分的变化。本综述的目的是基于免疫过程和嘌呤能信号通路来了解宫颈癌的病理生理学，并提出治疗靶点的可能性。
为了进行本次综述，从 Pubmed 中选择了涵盖宫颈癌、炎症和嘌呤能系统主题的研究。
主要涉及的促炎细胞因子有 IL-17、IL-1β、IL-6 和 IL-18，抗炎细胞因子中 IL-10 和 TGF-β 较为突出。作为新的治疗靶点，已经提出了 P2X7 和 A2A 受体，因为阻断 P2X7 会导致促炎细胞因子释放减少，而阻断 A2A 会增加肿瘤杀伤性 T 淋巴细胞在肿瘤对抗中的激活。免疫系统和嘌呤能系统之间的关联在其他类型的疾病中已经为人所知，这也为更好地理解宫颈癌的生物分子过程和治疗可能性提供了可能性。
