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1
Childhood asthma and puberty.儿童哮喘与青春期。
Arch Dis Child. 1985 Mar;60(3):231-5. doi: 10.1136/adc.60.3.231.
2
Growth and childhood asthma.生长与儿童哮喘。
Arch Dis Child. 1986 Nov;61(11):1049-55. doi: 10.1136/adc.61.11.1049.
3
[Anti-asthmatic agents. From pharmacology to clinical aspects].
Rev Med Liege. 1991 Feb;46(2):58-81.
4
Asthma pathogenesis and the implications for therapy in children.
Pediatr Clin North Am. 1992 Dec;39(6):1205-24. doi: 10.1016/s0031-3955(16)38441-3.
5
Pros and cons of cromolyn sodium prophylaxis. A summary of experiences with 70 asthmatic children.色甘酸钠预防治疗的利弊。70例哮喘患儿的经验总结。
Clin Pediatr (Phila). 1973 Sep;12(9):525-8.
6
Cromolyn sodium, five to six years later.
Ann Allergy. 1977 Aug;39(2):94-8.
7
Controversies in the pharmacotherapy of childhood asthma.
Prog Clin Biol Res. 1983;135:251-65.
8
[Bronchial asthma. Advances].
An Esp Pediatr. 1983 Sep;19 Suppl 19:17-24.
9
The place of cromolyn sodium in the long-term management of childhood asthma based on a 3- to 5-year follow-up.
J Pediatr. 1975 Sep;87(3):465-73. doi: 10.1016/s0022-3476(75)80663-9.
10
Management of chronic asthma.慢性哮喘的管理
Pediatr Clin North Am. 1992 Dec;39(6):1293-310. doi: 10.1016/s0031-3955(16)38446-2.

引用本文的文献

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The Association Between Female Smoking and Childhood Asthma Prevalence-A Study Based on Aggregative Data.女性吸烟与儿童哮喘患病率之间的关联——一项基于汇总数据的研究
Front Public Health. 2018 Oct 17;6:295. doi: 10.3389/fpubh.2018.00295. eCollection 2018.
2
Natural progression of childhood asthma symptoms and strong influence of sex and puberty.儿童哮喘症状的自然发展以及性别和青春期的强烈影响。
Ann Am Thorac Soc. 2014 Jul;11(6):939-44. doi: 10.1513/AnnalsATS.201402-084OC.
3
Paediatric origins of adult lung disease.成人肺部疾病的儿科根源。
Thorax. 2001 Feb;56(2):153-7. doi: 10.1136/thorax.56.2.153.
4
Effect of dampness at home in childhood on bronchial hyperreactivity in adolescence.童年时期家中潮湿对青少年支气管高反应性的影响。
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Progression of allergy and asthma through childhood to adolescence.过敏和哮喘从儿童期到青春期的进展。
Thorax. 1996 Jan;51 Suppl 1(Suppl 1):S3-6. doi: 10.1136/thx.51.suppl_1.s3.
6
Clinical pharmacology of asthma. Implications for treatment.哮喘的临床药理学。对治疗的启示。
Drugs. 1993 Nov;46(5):847-62. doi: 10.2165/00003495-199346050-00005.
7
Preschool wheezing and prognosis at 10.10岁时的学龄前喘息与预后
Arch Dis Child. 1986 Jul;61(7):642-6. doi: 10.1136/adc.61.7.642.

本文引用的文献

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The natural history of childhood asthma to adult life.儿童哮喘至成人期的自然病史。
Br Med J. 1980 Jun 14;280(6229):1397-1400. doi: 10.1136/bmj.280.6229.1397.
2
Antibodies to Herpesvirus hominis types 1 and 2 in malnourished Nigerian children.尼日利亚营养不良儿童中1型和2型人疱疹病毒抗体
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Death from asthma.死于哮喘。
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Variations in pattern of pubertal changes in girls.女孩青春期变化模式的差异。
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Spectrum of asthma in children. I. Clinical and physiological components.儿童哮喘的范围。I. 临床和生理组成部分。
Br Med J. 1973 Oct 6;4(5883):7-11. doi: 10.1136/bmj.4.5883.7.
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Long-term trial of disodium cromoglycate and isoprenaline in children with asthma.色甘酸钠与异丙肾上腺素治疗儿童哮喘的长期试验
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Asthma: current concepts.哮喘：当前概念
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Natural history of childhood asthma. 20-year follow-up.儿童哮喘的自然病史。20年随访。
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10
Comparison of cromoglycate (cromolyn) and theophylline in controlling symptoms of chronic asthma. A collaborative study.
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儿童哮喘与青春期。

Childhood asthma and puberty.

作者信息

Balfour-Lynn L

出版信息

Arch Dis Child. 1985 Mar;60(3):231-5. doi: 10.1136/adc.60.3.231.

DOI:10.1136/adc.60.3.231
PMID:3920976
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1777166/
Abstract

Thirty eight, chronic, perennial asthmatic children were prospectively examined every six months for a mean 8.9 years to clarify the relation between clinical asthma and puberty. Improvement in the disease occurred independent of puberty but the rate of improvement was appreciably greater during puberty. This led to speculation that improvement in childhood asthma could be associated with an immunological process capable of receiving a powerful stimulus from hormones active during puberty. In addition, children whose illness improved before any sign of puberty had developed could be confidently predicted to 'grow out' of their disease. Conversely, if no improvement was seen by the onset of puberty, a much more guarded prognosis was needed.

摘要

对38名慢性持续性哮喘儿童进行了前瞻性研究，每六个月检查一次，平均持续8.9年，以阐明临床哮喘与青春期之间的关系。疾病的改善与青春期无关，但在青春期期间改善率明显更高。这引发了一种推测，即儿童哮喘的改善可能与一种能够接受青春期活跃激素强烈刺激的免疫过程有关。此外，可以肯定地预测，在青春期任何迹象出现之前病情就已改善的儿童将会“摆脱”疾病。相反，如果到青春期开始时仍未见改善，则需要做出更为谨慎的预后判断。