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含植物源化合物的口腔黏膜喷雾剂用于治疗口腔感染性和炎症性疾病的研发与评价

Development and Evaluation of Oromucosal Spray Formulation Containing Plant-Derived Compounds for the Treatment of Infectious and Inflammatory Diseases of the Oral Cavity.

作者信息

Maslii Yuliia, Herbina Nataliia, Dene Lina, Ivanauskas Liudas, Bernatoniene Jurga

机构信息

Department of Drug Technology and Social Pharmacy, Lithuanian University of Health Sciences, LT-50161 Kaunas, Lithuania.

Department of Industrial Technology of Drugs, National University of Pharmacy, 61002 Kharkiv, Ukraine.

出版信息

Polymers (Basel). 2024 Sep 19;16(18):2649. doi: 10.3390/polym16182649.

DOI:10.3390/polym16182649
PMID:39339113
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11435575/
Abstract

According to data in the literature, natural products and essential oils are often used in dental practice. To develop a new oromucosal spray for the treatment of infectious and inflammatory diseases of the oral cavity, clove CO extract and essential oils of lavender and grapefruit were used as active pharmaceutical ingredients. Clove extract was obtained by the method of subcritical extraction from various raw materials, the choice of which was based on the yield of the CO extract and the study of its phytochemical and microbiological properties. Based on the results of microscopic and diffraction analyses, the rational time of ultrasonic exposure for the emulsion of active pharmaceutical ingredients was established. Mucoadhesive polymers were used as stabilizers of the two-phase system and prolongators. This article discusses the impact of the type and concentration of mucoadhesive polymers on the stability of the emulsion system; the viscous, textural, adhesive, and film characteristics of oromucosal spray; and the parameters determining sprayability.

摘要

根据文献数据，天然产物和精油常用于牙科实践。为开发一种用于治疗口腔感染性和炎症性疾病的新型口腔黏膜喷雾剂，丁香CO提取物以及薰衣草和葡萄柚精油被用作活性药物成分。丁香提取物通过亚临界萃取法从各种原料中获得，原料的选择基于CO提取物的得率及其植物化学和微生物特性研究。基于显微镜和衍射分析结果，确定了活性药物成分乳液超声处理的合理时间。黏膜黏附聚合物用作两相系统的稳定剂和延长剂。本文讨论了黏膜黏附聚合物的类型和浓度对乳液体系稳定性的影响；口腔黏膜喷雾剂的黏性、质地、黏附性和薄膜特性；以及决定喷雾性能的参数。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97ea/11435575/130b64a99531/polymers-16-02649-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97ea/11435575/73304e0ecce9/polymers-16-02649-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97ea/11435575/0766a139ae5e/polymers-16-02649-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97ea/11435575/679767142fbf/polymers-16-02649-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97ea/11435575/ddeca822db28/polymers-16-02649-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97ea/11435575/09a36f46825e/polymers-16-02649-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97ea/11435575/4003b2cc037a/polymers-16-02649-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97ea/11435575/2af5997b307b/polymers-16-02649-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97ea/11435575/ebc6fb8af33c/polymers-16-02649-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97ea/11435575/ae6bedbaf09e/polymers-16-02649-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97ea/11435575/c39eb0426ad1/polymers-16-02649-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97ea/11435575/130b64a99531/polymers-16-02649-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97ea/11435575/73304e0ecce9/polymers-16-02649-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97ea/11435575/0766a139ae5e/polymers-16-02649-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97ea/11435575/679767142fbf/polymers-16-02649-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97ea/11435575/ddeca822db28/polymers-16-02649-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97ea/11435575/09a36f46825e/polymers-16-02649-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97ea/11435575/4003b2cc037a/polymers-16-02649-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97ea/11435575/2af5997b307b/polymers-16-02649-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97ea/11435575/ebc6fb8af33c/polymers-16-02649-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97ea/11435575/ae6bedbaf09e/polymers-16-02649-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97ea/11435575/c39eb0426ad1/polymers-16-02649-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97ea/11435575/130b64a99531/polymers-16-02649-g011.jpg

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Int J Mol Sci. 2024 May 14;25(10):5359. doi: 10.3390/ijms25105359.
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Bioactive properties of clove () essential oil nanoemulsion: A comprehensive review.丁香（）精油纳米乳液的生物活性特性：综述。 需注意，原文中“clove ()”括号处内容缺失，可能影响对完整意思的准确理解。
Heliyon. 2023 Nov 30;10(1):e22437. doi: 10.1016/j.heliyon.2023.e22437. eCollection 2024 Jan 15.
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Citrus essential oils - Based nano-emulsions: Functional properties and potential applications.
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Food Chem X. 2023 Oct 31;20:100960. doi: 10.1016/j.fochx.2023.100960. eCollection 2023 Dec 30.
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Current and Potential Applications of Monoterpenes and Their Derivatives in Oral Health Care.单萜及其衍生物在口腔保健中的当前和潜在应用。
Molecules. 2023 Oct 19;28(20):7178. doi: 10.3390/molecules28207178.
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Novel tetrahydrocurcumin integrated mucoadhesive nanocomposite κ-carrageenan/xanthan gum sponges: a strategy for effective local treatment of oral cancerous and precancerous lesions.新型四氢姜黄素整合黏附纳米复合κ-卡拉胶/黄原胶海绵：一种有效治疗口腔癌前病变的局部治疗策略。
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