Pisani Silvia, Dorati Rossella, Chiesa Enrica, Genta Ida, Modena Tiziana, Bruni Giovanna, Grisoli Pietro, Conti Bice
Department of Drug Sciences, University of Pavia, Viale Taramelli 12/14, 27100 Pavia, Italy.
Polymerix S.r.l., Via Taramelli 24, 27100 Pavia, Italy.
Pharmaceutics. 2019 Apr 3;11(4):161. doi: 10.3390/pharmaceutics11040161.
The advent and growth of resistance phenomena to antibiotics has reached critical levels, invalidating the action of a majority of antibiotic drugs currently used in the clinical field. Several innovative techniques, such as the nanotechnology, can be applied for creating innovative drug delivery systems designed to modify drug release itself and/or drug administration route; moreover, they have proved suitable for overcoming the phenomenon of antibiotic resistance. Electrospun nanofibers, due to their useful structural properties, are showing promising results as antibiotic release devices for preventing bacteria biofilm formation after surgical operation and for limiting resistance phenomena. In this work gentamicin sulfate (GS) was loaded into polylactide-co-polycaprolactone (PLA-PCL) electrospun nanofibers; quantification and in vitro drug release profiles in static and dynamic conditions were investigated; GS kinetic release from nanofibers was studied using mathematical models. A preliminary microbiological test was carried out towards Staphylococcus aureus and Escherichia coli bacteria.
抗生素耐药现象的出现和发展已达到临界水平，使目前临床领域使用的大多数抗生素药物失效。几种创新技术，如纳米技术，可用于创建创新的药物递送系统，旨在改变药物释放本身和/或给药途径；此外，它们已被证明适用于克服抗生素耐药现象。电纺纳米纤维因其有用的结构特性，作为抗生素释放装置在预防外科手术后细菌生物膜形成和限制耐药现象方面显示出有前景的结果。在这项工作中，将硫酸庆大霉素（GS）负载到聚乳酸-共-聚己内酯（PLA-PCL）电纺纳米纤维中；研究了静态和动态条件下的定量和体外药物释放曲线；使用数学模型研究了GS从纳米纤维中的动力学释放。对金黄色葡萄球菌和大肠杆菌进行了初步微生物测试。
