R&D Center, LG Household and Health Care, Ltd., Seoul, Korea.
PLoS One. 2019 Apr 16;14(4):e0215244. doi: 10.1371/journal.pone.0215244. eCollection 2019.
In the stratum corneum, the intercellular junction made up of cadherin proteins provides the structural integrity of the framework. Ca2+ ions are known to play a key role in maintaining this junction. In this study, we hypothesized that Ca2+ chelation in stratum corneum will weaken the bond of the tissue and consequently promote exfoliation. Amino acids, ubiquitously existing as metabolites and building blocks of the body, have the molecular property to chelate Ca2+ ions. In the current study, we verified the Ca2+ chelating property of amino acids and demonstrated that amino acids can interfere with the interaction of cadherins, separate stratum corneum into pieces, and thereby stimulate the exfoliation process of skin. These results validate the importance of Ca2+ ion in the skin exfoliation process. Importantly, our findings indicate that amino acids may be efficiently used for improving skin conditions.
在角质层中，由钙黏蛋白组成的细胞间连接提供了框架的结构完整性。已知钙离子在维持这种连接中起着关键作用。在这项研究中，我们假设角质层中的钙离子螯合作用会削弱组织的结合，从而促进剥落。氨基酸作为代谢物和身体的构建块普遍存在，具有螯合钙离子的分子特性。在目前的研究中，我们验证了氨基酸的钙离子螯合特性，并证明氨基酸可以干扰钙黏蛋白的相互作用，将角质层分离成碎片，从而刺激皮肤的剥落过程。这些结果验证了钙离子在皮肤剥落过程中的重要性。重要的是，我们的发现表明氨基酸可能被有效地用于改善皮肤状况。
