CRMSB, UMR 5536, CNRS/University of Bordeaux, 146 Rue Léo Saignat, 33076 Bordeaux Cedex, France.
CRMSB, UMR 5536, CNRS/University of Bordeaux, 146 Rue Léo Saignat, 33076 Bordeaux Cedex, France; Department of Physiology, 7 Rue du Bugnon, CH1005 Lausanne, Switzerland.
Brain Res. 2019 Aug 15;1717:86-94. doi: 10.1016/j.brainres.2019.04.012. Epub 2019 Apr 13.
Hypoxia-ischemia (HI) remains a major cause of perinatal mortality and chronic disability in newborns worldwide (1-6 for 1000 births) with a high risk of future motor, behavioral and neurological deficits. Keeping newborns under moderate hypothermia is the unique therapeutic approach but is not sufficiently successful as nearly 50% of infants do not respond to it. In a 7-day post-natal rat model of HI, we used pregnant and breastfeeding female nutritional supplementation with piceatannol (PIC), a polyphenol naturally found in berries, grapes and passion fruit, as a neuroprotective strategy. Maternal supplementation led to neuroprotection against neonate brain damage and reversed their sensorimotor deficits as well as cognitive impairments. Neuroprotection of per os maternal supplementation with PIC is a preventive strategy to counteract brain damage in pups induced by HI. This nutritional approach could easily be adopted as a preventive strategy in humans.
缺氧缺血性（HI）仍然是全球围产期死亡和新生儿慢性残疾的主要原因（每 1000 例活产中有 1-6 例），未来存在运动、行为和神经发育缺陷的高风险。使新生儿保持适度低温是唯一的治疗方法，但效果并不理想，因为近 50%的婴儿对此没有反应。在 HI 的 7 天产后大鼠模型中，我们使用了一种多聚酚类物质白藜芦醇（PIC），这是一种天然存在于浆果、葡萄和西番莲果中的多酚，对怀孕和哺乳期的雌性进行营养补充，作为一种神经保护策略。母体补充 PIC 可防止新生儿大脑损伤，并逆转其感觉运动缺陷和认知障碍。通过口服给予 PIC 的母体补充的神经保护是一种预防策略，可以对抗 HI 引起的幼仔脑损伤。这种营养方法很容易在人类中被采用作为预防策略。
