Hospital Israelita Albert Einstein, Av. Albert Einstein, 627/520 São Paulo, São Paulo, CEP 05651-901, Brazil.
Hospital Israelita Albert Einstein, Av. Albert Einstein, 627/520 São Paulo, São Paulo, CEP 05651-901, Brazil; Pathology Department, School of Dentistry, University of São Paulo, Av. Professor Lineu Prestes 2227, CEP 05508-000, Brazil.
Photodiagnosis Photodyn Ther. 2019 Jun;26:284-286. doi: 10.1016/j.pdpdt.2019.04.013. Epub 2019 Apr 13.
P. aeruginosa is a gram-negative bacterium present in nosocomial infections with high morbidity and mortality. This microorganism is frequently resistant to antibiotics, leading to clinical complications. In the present report, we described a clinical case of a patient with severe oral lesions caused by P. aeruginosa, which was refractory to antibiotics treatment and presented positive clinical outcomes after some sessions of antimicrobial photodynamic inactivation (API) mediated by methylene blue dye. We discuss the potential of API for P. aeruginosa refractory infections and possible resistance mechanisms of this microorganism to different API protocols.
铜绿假单胞菌是一种革兰氏阴性菌，存在于医院感染中，具有较高的发病率和死亡率。这种微生物经常对抗生素产生耐药性，导致临床并发症。在本报告中，我们描述了一例由铜绿假单胞菌引起的严重口腔病变患者的临床病例，该患者对抗生素治疗有抗药性，在经过几次亚甲蓝介导的光动力抗菌处理（API）后，临床结果呈阳性。我们讨论了 API 治疗铜绿假单胞菌难治性感染的潜力，以及这种微生物对不同 API 方案的可能耐药机制。
