Ghapanchi Jannan, Farahmand Hanieh, Bazargani Abdollah, Zekavat Seyed Omid Reza, Lavaee Fatemeh, Ojaghi Amir Hossein
Oral and Dental Diseases Research Center, Dept. of Oral Medicine, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
Post Graduate Student, Dept. of Oral and Maxillofacial Medicine, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
J Dent (Shiraz). 2024 Mar 1;25(1):45-50. doi: 10.30476/dentjods.2023.97098.1989. eCollection 2024 Mar.
STATEMENT OF THE PROBLEM: Patients with leukemia are prone to infectious and often life-threatening complications. Evidence suggests that a specific oral microbiota may contribute to septicemia, which can delay antineoplastic treatment, compromise treatment efficacy, or even endanger patients' lives.
This study investigated the prevalence of and in the saliva of patients with acute myeloid leukemia who were candidates for bone marrow transplantation.
This cross-sectional study was conducted in 2019 in the Hematology-Oncology Department of Namazi Hospital, Shiraz University of Medical Sciences. The study included 28 patients with acute myeloid leukemia eligible for bone marrow transplantation as the case group and age- and sex-matched healthy individuals as the control group. Unstimulated saliva samples were collected to determine the frequency of and . Data were analyzed using SPSS version 18, the chi-square test, and the independent t-test.
In the patients with acute myeloid leukemia, 26 (86%) were positive for and 18 (60%) were positive for . In the healthy group, 11 (22.9%) were positive for and 3 (6.2%) were positive for . The frequency of and in the saliva samples of patients with acute myeloid leukemia was significantly higher than in the healthy control subjects ( value < 0.05). Chi-square test showed no significant association between age and the frequency of bacteria ( value= 0.27).
In the current study, the frequency of and in the saliva of patients with acute myeloid leukemia was higher than in the healthy control group.
白血病患者容易发生感染性且往往危及生命的并发症。有证据表明，特定的口腔微生物群可能导致败血症，这可能会延迟抗肿瘤治疗、损害治疗效果，甚至危及患者生命。
本研究调查了有资格接受骨髓移植的急性髓系白血病患者唾液中[具体细菌名称1]和[具体细菌名称2]的流行情况。
这项横断面研究于2019年在设拉子医科大学纳马齐医院血液肿瘤科进行。该研究包括28例有资格接受骨髓移植的急性髓系白血病患者作为病例组，以及年龄和性别匹配的健康个体作为对照组。收集未刺激的唾液样本以确定[具体细菌名称1]和[具体细菌名称2]的频率。使用SPSS 18版、卡方检验和独立t检验对数据进行分析。
在急性髓系白血病患者中，26例（86%）[具体细菌名称1]呈阳性，18例（60%）[具体细菌名称2]呈阳性。在健康组中，11例（22.9%）[具体细菌名称1]呈阳性，3例（6.2%）[具体细菌名称2]呈阳性。急性髓系白血病患者唾液样本中[具体细菌名称1]和[具体细菌名称2]的频率显著高于健康对照受试者（P值<0.05）。卡方检验显示年龄与细菌频率之间无显著关联（P值=0.27）。
在本研究中，急性髓系白血病患者唾液中[具体细菌名称1]和[具体细菌名称2]的频率高于健康对照组。
