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一个对DNA损伤有反应的黑腹果蝇基因也受热激诱导。

A DNA damage-responsive Drosophila melanogaster gene is also induced by heat shock.

作者信息

Vivino A A, Smith M D, Minton K W

出版信息

Mol Cell Biol. 1986 Dec;6(12):4767-9. doi: 10.1128/mcb.6.12.4767-4769.1986.

DOI:10.1128/mcb.6.12.4767-4769.1986
PMID:3099173
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC367266/
Abstract

A gene isolated by screening Drosophila melanogaster tissue culture cells for DNA damage regulation was also found to be regulated by heat shock. After UV irradiation or heat shock, induction is at the transcriptional level and results in the accumulation of a 1.0-kilobase polyadenylated transcript. The restriction map of the clone bears no resemblance to the known heat shock genes, which are shown to be uninduced by UV irradiation.

摘要

通过筛选黑腹果蝇组织培养细胞以寻找DNA损伤调节相关基因时分离出的一个基因，也被发现受热激调节。紫外线照射或热激后，诱导发生在转录水平，并导致一个1.0千碱基的多聚腺苷酸化转录本积累。该克隆的限制酶切图谱与已知的热激基因毫无相似之处，已知热激基因在紫外线照射下不会被诱导。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/591c/367266/cf476add363b/molcellb00096-0635-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/591c/367266/c08057e2d436/molcellb00096-0634-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/591c/367266/5a76cd8b8c5c/molcellb00096-0634-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/591c/367266/827c56ae5a91/molcellb00096-0634-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/591c/367266/cf476add363b/molcellb00096-0635-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/591c/367266/c08057e2d436/molcellb00096-0634-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/591c/367266/5a76cd8b8c5c/molcellb00096-0634-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/591c/367266/827c56ae5a91/molcellb00096-0634-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/591c/367266/cf476add363b/molcellb00096-0635-a.jpg

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A DNA damage-responsive Drosophila melanogaster gene is also induced by heat shock.一个对DNA损伤有反应的黑腹果蝇基因也受热激诱导。
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引用本文的文献

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本文引用的文献

1
Cloning and characterization of nine heat-shock-induced mRNAs of Drosophila melanogaster.黑腹果蝇九个热休克诱导mRNA的克隆与特性分析
Gene. 1981 Oct;15(1):67-80. doi: 10.1016/0378-1119(81)90105-0.
2
The occurrence of DNA strand breaks after hyperthermic treatments of mammalian cells with and without radiation.对哺乳动物细胞进行有辐射和无辐射的热疗后DNA链断裂的发生情况。
Radiat Res. 1984 Apr;98(1):198-208.
3
Transcripts of the six Drosophila actin genes accumulate in a stage- and tissue-specific manner.六种果蝇肌动蛋白基因的转录本以阶段和组织特异性的方式积累。
Cell. 1983 May;33(1):115-23. doi: 10.1016/0092-8674(83)90340-9.
4
groEL and dnaK genes of Escherichia coli are induced by UV irradiation and nalidixic acid in an htpR+-dependent fashion.大肠杆菌的groEL和dnaK基因以依赖htpR⁺的方式被紫外线照射和萘啶酸诱导。
Proc Natl Acad Sci U S A. 1984 Mar;81(5):1499-503. doi: 10.1073/pnas.81.5.1499.
5
The actin genes of Drosophila: a dispersed multigene family.果蝇的肌动蛋白基因：一个分散的多基因家族。
Cell. 1980 Feb;19(2):365-78. doi: 10.1016/0092-8674(80)90511-5.
6
Inducible DNA repair systems.可诱导的DNA修复系统。
Annu Rev Biochem. 1985;54:425-57. doi: 10.1146/annurev.bi.54.070185.002233.
7
Induction of metallothionein and other mRNA species by carcinogens and tumor promoters in primary human skin fibroblasts.致癌物和肿瘤启动子对原代人皮肤成纤维细胞中金属硫蛋白及其他信使核糖核酸种类的诱导作用。
Mol Cell Biol. 1986 May;6(5):1760-6. doi: 10.1128/mcb.6.5.1760-1766.1986.
8
DNA damage and heat shock dually regulate genes in Saccharomyces cerevisiae.DNA损伤和热休克双重调控酿酒酵母中的基因。
Mol Cell Biol. 1986 Jan;6(1):90-6. doi: 10.1128/mcb.6.1.90-96.1986.
9
SOS response in mammalian cells.
Cancer Invest. 1985;3(2):163-74. doi: 10.3109/07357908509017499.
10
Screening of lambda library for differentially expressed genes using in vitro transcripts.使用体外转录本筛选λ文库中的差异表达基因。
Anal Biochem. 1985 Nov 1;150(2):429-41. doi: 10.1016/0003-2697(85)90532-9.