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本文引用的文献

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The Network for Analysing Longitudinal Population-based HIV/AIDS data on Africa (ALPHA): Data on mortality, by HIV status and stage on the HIV care continuum, among the general population in seven longitudinal studies between 1989 and 2014.非洲纵向人群艾滋病毒/艾滋病数据分析网络(ALPHA):1989年至2014年期间七项纵向研究中普通人群基于艾滋病毒状况和艾滋病毒护理连续阶段的死亡率数据。
Gates Open Res. 2017 Nov 6;1:4. doi: 10.12688/gatesopenres.12753.1.
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The impact of programs for prevention of mother-to-child transmission of HIV on health care services and systems in sub-Saharan Africa - A review.撒哈拉以南非洲地区预防艾滋病母婴传播项目对卫生保健服务及系统的影响——一项综述
Public Health Rev. 2017 Dec 5;38:28. doi: 10.1186/s40985-017-0072-5. eCollection 2017.
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Retention in HIV Care During Pregnancy and the Postpartum Period in the Option B+ Era: Systematic Review and Meta-Analysis of Studies in Africa.在“B+方案”时代,艾滋病毒母婴传播阻断项目中孕妇和产后妇女的艾滋病毒护理保留情况:非洲研究的系统评价和荟萃分析。
J Acquir Immune Defic Syndr. 2018 Apr 15;77(5):427-438. doi: 10.1097/QAI.0000000000001616.
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From policy to practice: exploring the implementation of antiretroviral therapy access and retention policies between 2013 and 2016 in six sub-Saharan African countries.从政策到实践:探索2013年至2016年期间撒哈拉以南非洲六个国家抗逆转录病毒疗法获取与留存政策的实施情况。
BMC Health Serv Res. 2017 Nov 21;17(1):758. doi: 10.1186/s12913-017-2678-1.
5
Implementation effectiveness of revised (post-2010) World Health Organization guidelines on prevention of mother-to-child transmission of HIV using routinely collected data in sub-Saharan Africa: A systematic literature review.利用撒哈拉以南非洲地区常规收集的数据,评估修订后(2010年之后)世界卫生组织预防母婴传播艾滋病毒指南的实施效果:一项系统文献综述
Medicine (Baltimore). 2017 Oct;96(40):e8055. doi: 10.1097/MD.0000000000008055.
6
Identifying gaps in HIV policy and practice along the HIV care continuum: evidence from a national policy review and health facility surveys in urban and rural Kenya.识别艾滋病防治连续体中艾滋病政策和实践的差距:来自肯尼亚城乡国家政策审查和卫生机构调查的证据。
Health Policy Plan. 2017 Nov 1;32(9):1316-1326. doi: 10.1093/heapol/czx091.
7
Prevention of mother-to-child transmission of HIV Option B+ cascade in rural Tanzania: The One Stop Clinic model.坦桑尼亚农村地区预防艾滋病母婴传播的B+方案级联:一站式诊所模式。
PLoS One. 2017 Jul 12;12(7):e0181096. doi: 10.1371/journal.pone.0181096. eCollection 2017.
8
Overcoming Health System Challenges for Women and Children Living With HIV Through the Global Plan.通过全球计划克服感染艾滋病毒妇女和儿童面临的卫生系统挑战。
J Acquir Immune Defic Syndr. 2017 May 1;75 Suppl 1(Suppl 1):S76-S85. doi: 10.1097/QAI.0000000000001336.
9
Lessons Learned From Option B+ in the Evolution Toward "Test and Start" From Malawi, Cameroon, and the United Republic of Tanzania.从马拉维、喀麦隆和坦桑尼亚联合共和国在向“检测即治疗”演进过程中的“B+方案”中汲取的经验教训。
J Acquir Immune Defic Syndr. 2017 May 1;75 Suppl 1(Suppl 1):S43-S50. doi: 10.1097/QAI.0000000000001326.
10
Integrating PMTCT Into Maternal, Newborn, and Child Health and Related Services: Experiences From the Global Plan Priority Countries.将预防母婴传播纳入孕产妇、新生儿和儿童健康及相关服务:全球计划重点国家的经验
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实施 2013-2016 年南非马拉维、坦桑尼亚联合共和国农村地区母婴传播艾滋病毒预防政策。

Implementing prevention policies for mother-to-child transmission of HIV in rural Malawi, South Africa and United Republic of Tanzania, 2013-2016.

机构信息

Department of Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, England.

Malawi Epidemiology and Intervention Research Unit, Lilongwe, Malawi.

出版信息

Bull World Health Organ. 2019 Mar 1;97(3):200-212. doi: 10.2471/BLT.18.217471. Epub 2019 Jan 28.

DOI:10.2471/BLT.18.217471
PMID:30992633
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6453322/
Abstract

OBJECTIVE

To assess adoption of World Health Organization (WHO) guidance into national policies for prevention of mother-to-child transmission (PMTCT) of human immunodeficiency virus (HIV) and to monitor implementation of guidelines at facility level in rural Malawi, South Africa and the United Republic of Tanzania.

METHODS

We summarized national PMTCT policies and WHO guidance for 15 indicators across the cascades of maternal and infant care over 2013-2016. Two survey rounds were conducted (2013-2015 and 2015-2016) in 46 health facilities serving five health and demographic surveillance system populations. We administered structured questionnaires to facility managers to describe service delivery. We report the proportions of facilities implementing each indicator and the frequency and durations of stock-outs of supplies, by site and survey round.

FINDINGS

In all countries, national policies influencing the maternal and infant PMTCT cascade of care aligned with WHO guidelines by 2016; most inter-country policy variations concerned linkage to routine HIV care. The proportion of facilities delivering post-test counselling, same-day antiretroviral therapy (ART) initiation, antenatal care and ART provision in the same building, and Option B+ increased or remained at 100% in all sites. Progress in implementing policies on infant diagnosis and treatment varied across sites. Stock-outs of HIV test kits or antiretroviral drugs in the past year declined overall, but were reported by at least one facility per site in both rounds.

CONCLUSION

Progress has been made in implementing PMTCT policy in these settings. However, persistent gaps across the infant cascade of care and supply-chain challenges, risk undermining infant HIV elimination goals.

摘要

目的

评估世界卫生组织(WHO)指导方针在各国预防母婴传播(PMTCT)艾滋病毒(HIV)政策中的采用情况,并监测南非、马拉维共和国和坦桑尼亚联合共和国农村地区设施层面指南的执行情况。

方法

我们总结了 2013-2016 年间母婴护理级联的 15 项指标的国家 PMTCT 政策和 WHO 指南。在为五个卫生和人口监测系统人群服务的 46 个卫生设施中进行了两轮调查(2013-2015 年和 2015-2016 年)。我们向设施管理人员发放了结构化问卷,以描述服务提供情况。我们按地点和调查轮次报告实施每个指标的设施比例以及供应品缺货的频率和持续时间。

发现

到 2016 年,所有国家影响母婴 PMTCT 级联护理的国家政策都与 WHO 指南一致;大多数国家间政策差异涉及与常规 HIV 护理的联系。在所有地点,提供检测后咨询、同日开始抗逆转录病毒治疗(ART)、在同一栋楼内进行产前护理和提供 ART,以及实施 B+方案的设施比例均增加或保持在 100%。在实施婴儿诊断和治疗政策方面,各地进展情况各不相同。在过去一年中,艾滋病毒检测试剂盒或抗逆转录病毒药物的缺货情况总体上有所减少,但在两轮调查中,每个地点都至少有一家设施报告存在缺货情况。

结论

在这些环境中,PMTCT 政策的实施已经取得进展。然而,婴儿级联护理和供应链挑战方面仍然存在差距,这可能会破坏婴儿艾滋病毒消除目标。