Faculty of Medicine and Health Technology, Tampere University, Tampere.
South-Karelia Central Hospital, Finland.
Cardiol J. 2021;28(2):302-311. doi: 10.5603/CJ.a2019.0037. Epub 2019 Apr 17.
Long-term outcome of the three categories of acute coronary syndrome (ACS) in real-life patient cohorts is not well known. The objective of this study was to survey the 10-year outcome of an ACS patient cohort admitted to a university hospital and to explore factors affecting the outcome.
A total of 1188 consecutive patients (median age 73 years) with ST-elevation myocardial infarction (STEMI), non-ST-elevation myocardial infarction (NSTEMI) or unstable angina pectoris (UA) in 2002-2003 were included and followed up for ≥ 10 years.
Mortality for STEMI, NSTEMI and UA patients during the follow-up period was 52.5%, 69.9% and 41.0% (p < 0.001), respectively. In multivariable Cox regression analysis, only age and creatinine level at admission were independently associated with patient outcome in all the three ACS categories when analyzed separately.
All the three ACS categories proved to have high mortality rates during long-term followup in a real-life patient cohort. NSTEMI patients had worse outcome than STEMI and UA patients during the whole follow-up period. Our study results indicate clear differences in the prognostic significance of various demographic and therapeutic parameters within the three ACS categories.
在真实患者队列中，三种急性冠状动脉综合征（ACS）类别的长期预后尚不清楚。本研究的目的是调查 2002-2003 年入住大学医院的 ACS 患者队列的 10 年预后，并探讨影响预后的因素。
共纳入 1188 例连续 ST 段抬高型心肌梗死（STEMI）、非 ST 段抬高型心肌梗死（NSTEMI）或不稳定型心绞痛（UA）患者（中位数年龄 73 岁），并随访≥10 年。
STEMI、NSTEMI 和 UA 患者在随访期间的死亡率分别为 52.5%、69.9%和 41.0%（p<0.001）。在多变量 Cox 回归分析中，当分别分析时，仅年龄和入院时的肌酐水平与所有三种 ACS 类别的患者预后独立相关。
在真实患者队列的长期随访中，三种 ACS 类别均证明具有高死亡率。NSTEMI 患者在整个随访期间的预后比 STEMI 和 UA 患者差。我们的研究结果表明，三种 ACS 类别中各种人口统计学和治疗参数的预后意义存在明显差异。
