Luquetti A O, Miles M A, Rassi A, de Rezende J M, de Souza A A, Póvoa M M, Rodrigues I
Trans R Soc Trop Med Hyg. 1986;80(3):462-70. doi: 10.1016/0035-9203(86)90347-0.
The clinical characteristics of acute and chronic Chagas' disease in central Brazil are described (29 acute cases and 111 chronic cases). The geographical distribution of Trypanosoma cruzi zymodemes in this region was mapped. Zymodeme (Z) 1 was identified in 12 acute cases, Z2 in 13 and repeated xenodiagnosis gave the same zymodeme identification. The clinical pictures of the Z1 and Z2 acute phases were similar. Resistance to benznidazole treatment occurred after either Z1 or Z2 acute infections. Only 14 positive xenodiagnosis were obtained from the 111 chronic phase patients examined. For 12 of these 14 patients the zymodeme was identified. All 12 carried Z2, 10 of whom had mega involvement. There were several possible explanations for the failure to detect T. cruzi Z1 in chronic Chagas' disease with mega syndromes: suggestions were made for follow-up investigations.
本文描述了巴西中部急性和慢性恰加斯病的临床特征（29例急性病例和111例慢性病例）。绘制了该地区克氏锥虫酶解电泳类型的地理分布图。在12例急性病例中鉴定出酶解电泳类型（Z）1，13例中鉴定出Z2，重复的异种接种诊断得到相同的酶解电泳类型鉴定结果。Z1和Z2急性期的临床症状相似。Z1或Z2急性感染后出现对苯硝唑治疗的耐药性。在检查的111例慢性期患者中仅获得14次阳性异种接种诊断结果。在这14例患者中的12例鉴定出了酶解电泳类型。所有12例均携带Z2，其中10例有巨症表现。对于在患有巨症综合征的慢性恰加斯病中未能检测到克氏锥虫Z1，有几种可能的解释：并提出了后续调查的建议。
