血清S100A8/A9作为炎症性肠病潜在的敏感生物标志物
Serum S100A8/A9 as a Potentially Sensitive Biomarker for Inflammatory Bowel Disease.
作者信息
Okada Kohki, Okabe Makoto, Kimura Yuto, Itoh Hiroshi, Ikemoto Masaki
机构信息
Department of Medical Technology and Sciences, Faculty of Health Sciences, Kyoto Tachibana University, Kyoto, Japan.
Department of Clinical Laboratory Science, Faculty of Health Care, Tenri Health Care University, Tenri, Japan.
出版信息
Lab Med. 2019 Oct 10;50(4):370-380. doi: 10.1093/labmed/lmz003.
BACKGROUND
The clinical significance of human S100A8/A9 (h-S100A8/A9) in patients with inflammatory bowel disease (IBD) is poorly understood.
OBJECTIVE
To clarify whether serum S100A8/A9 is a sensitive biomarker for IBD.
METHODS
Serum specimens from outpatients with IBD (n = 101) and healthy volunteers (HVs) (n = 101) were used in this study. Enzyme-linked immunosorbent assays for h-S100A8/A9 and inflammatory cytokines were performed using these specimens. Further, correlation analysis was performed to investigate the significance of h-S100A8/A9 fluctuation in patients with IBD.
RESULTS
The average of serum h-S100A8/A9 concentration in outpatients with IBD was significantly higher than that in HVs. The concentration of h-S100A8/A9 in patients with IBD was barely correlated with that of CRP and inflammatory cytokines. Despite that finding, the serum level of h-S100A8/A9 in patients with ulcerative colitis (UC) was correlated with the severity of IBD, compared with other inflammatory proteins.
CONCLUSION
Serum h-S100A8/A9 is superior to CRP as a sensitive biomarker for IBD.
背景
人类S100A8/A9（h-S100A8/A9）在炎症性肠病（IBD）患者中的临床意义尚不清楚。
目的
阐明血清S100A8/A9是否为IBD的敏感生物标志物。
方法
本研究使用了IBD门诊患者（n = 101）和健康志愿者（HV，n = 101）的血清标本。使用这些标本进行h-S100A8/A9和炎性细胞因子的酶联免疫吸附测定。此外，进行相关性分析以研究IBD患者中h-S100A8/A9波动的意义。
结果
IBD门诊患者血清h-S100A8/A9浓度的平均值显著高于健康志愿者。IBD患者中h-S100A8/A9的浓度与CRP和炎性细胞因子的浓度几乎没有相关性。尽管有这一发现，但与其他炎性蛋白相比，溃疡性结肠炎（UC）患者血清h-S100A8/A9水平与IBD严重程度相关。
结论
血清h-S100A8/A9作为IBD的敏感生物标志物优于CRP。
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