Aleksandrova I A, Moroz A F, Antsiferova N G, Aleksandrov A D
Zh Mikrobiol Epidemiol Immunobiol. 1986 Oct(10):72-5.
The study has revealed the fundamental possibility, and established the concrete conditions of obtaining standard erythrocyte polyvalent diagnosticum for the detection of antibodies to the antigens of P. aeruginosa, belonging to 5 types most frequently occurring in clinical practice, in the passive hemagglutination test. The data on high type- and species-specificity of the new erythrocyte diagnosticum have been obtained, which indicates that slime antigens have been correctly chosen as sensitins and confirms the necessity of using the polyvalent preparation. Preliminary data on the clinical trial of the erythrocyte diagnosticum show the expediency of its use for the control of specific immune response in donors in the process of obtaining anti-P. aeruginosa hyperimmune plasma, as well as the possibility of using this method for the serological diagnosis of P. aeruginosa infection. The diagnostic preparation has been found to retain its activity for 10 months (the term of observation).
该研究揭示了基本可能性，并确定了在被动血凝试验中获得用于检测铜绿假单胞菌抗原抗体的标准红细胞多价诊断制剂的具体条件，这些抗原属于临床实践中最常见的5种类型。已获得关于新型红细胞诊断制剂高型特异性和种特异性的数据，这表明黏液抗原已被正确选作致敏素，并证实了使用多价制剂的必要性。红细胞诊断制剂临床试验的初步数据表明，在获取抗铜绿假单胞菌超免疫血浆过程中，将其用于监测供体的特异性免疫反应是可行的，并且该方法可用于铜绿假单胞菌感染的血清学诊断。已发现该诊断制剂在10个月（观察期）内保持其活性。
