Occupational and Environmental Health Group, National Institute of Health, Colombia.
Public Health Department, School of Medicine, Universidad Industrial de Santander, Colombia.
Ind Health. 2020 Feb 4;58(1):15-21. doi: 10.2486/indhealth.2018-0111. Epub 2019 Apr 18.
This study explored the potential association between chronic exposure to pesticide mixtures including paraquat and respiratory outcomes among Colombian farmers. Sociodemographic and occupational data, respiratory symptoms and spirometric data were collected. Paraquat in spot urine samples were quantified with solid-phase extraction high-performance liquid chromatography. Multiple Poisson regressions with robust variance were used to determine factors associated with respiratory outcomes. Profiles of pesticide mixtures used were identified among 217 farmworkers, but profenofos and methamidophos-based mixtures were more frequent. Chronic paraquat exposure was slightly associated with self-reported asthma (PR: 1.06; 95% CI 1.00 to 1.13). Different pesticide mixtures were associated with flu, thoracic pain, allergic rhinitis, and obstructive pattern in spirometry. Although acute exposure to paraquat is low among Colombian farmers participating in the study, associations between respiratory outcomes and chronic pesticide mixtures exposure including profenofos, methamidophos or glyphosate require further specific studies.
本研究探讨了包括百草枯在内的农药混合物慢性暴露与哥伦比亚农民呼吸系统结局之间的潜在关联。收集了社会人口统计学和职业数据、呼吸症状和肺功能数据。采用固相萃取高效液相色谱法定量检测尿样中的百草枯。使用稳健方差的多泊松回归来确定与呼吸结局相关的因素。在 217 名农场工人中确定了农药混合物的使用情况，但以丙溴磷和甲胺磷为基础的混合物更为常见。慢性百草枯暴露与自述哮喘有轻微关联（PR：1.06；95%CI 1.00 至 1.13）。不同的农药混合物与流感、胸痛、过敏性鼻炎和肺功能检查中的阻塞模式有关。尽管参与研究的哥伦比亚农民急性百草枯暴露水平较低，但包括丙溴磷、甲胺磷或草甘膦在内的慢性农药混合物暴露与呼吸结局之间的关联需要进一步的专门研究。
