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用于新型复合光热材料的锰铁氧体纳米颗粒的合成及后续普鲁士蓝功能化

Synthesis of MnFeO Nanoparticles and Subsequent Prussian Blue Functionalization for a Novel Composite Photothermal Material.

作者信息

Wang Mengyu, Zhang Ming, Liang Zhihan, Su Min

机构信息

School of Chemical Engineering, Hebei University of Technology, Tianjin 300401, China.

Xiucun Pharmaceutical Development Co., Ltd., Tianjin 300450, China.

出版信息

Nanomaterials (Basel). 2025 Sep 8;15(17):1382. doi: 10.3390/nano15171382.

DOI:10.3390/nano15171382
PMID:40938060
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12430317/
Abstract

MnFeO magnetic nanoparticles have shown broad application prospects in the field of tumor diagnosis and treatment; however, precise particle size regulation within the 100-200 nm range, as well as the synergistic integration of physical and medical functionalities, remains challenging. As a commonly used method for synthesizing MnFeO nanoparticles, the solvothermal method has been proven to enable the regulation of the particle size of products, particularly its ability to utilize the viscosity of solvents as a method for particle size regulation. Therefore, this work investigates the influence of the diethylene glycol (DEG) to ethylene glycol (EG) ratio on particle size regulation in solvothermal synthesis of MnFeO nanoparticles, and constructs MnFeO@PB nanocomposite materials. The results demonstrate that with the DEG ratio increasing from 0 to 80% in a DEG:EG mixed solvent system, the average particle size of MnFeO nanoparticles can be reduced from 266 nm to 105 nm. The MPB4.5 sample (MnFeO:PB molar ratio = 5:4.5 in the MnFeO@PB nanostructure) exhibits an optimal photothermal heating effect and good photothermal stability, demonstrating potential as a photothermal therapeutic agent. The resultant MnFeO@PB system provides a strategy for precise particle size regulation and functional integration for photothermal therapy of tumors with magnetic targeting potential.

摘要

锰铁氧体磁性纳米粒子在肿瘤诊断和治疗领域已展现出广阔的应用前景；然而，在100 - 200纳米范围内精确调控粒径，以及将物理功能与医学功能进行协同整合，仍然具有挑战性。作为一种常用的合成锰铁氧体纳米粒子的方法，溶剂热法已被证明能够调控产物的粒径，特别是其利用溶剂粘度作为粒径调控方法的能力。因此，本工作研究了二甘醇（DEG）与乙二醇（EG）的比例对溶剂热合成锰铁氧体纳米粒子粒径调控的影响，并构建了锰铁氧体@PB纳米复合材料。结果表明，在DEG:EG混合溶剂体系中，随着DEG比例从0增加到80%，锰铁氧体纳米粒子的平均粒径可从266纳米减小到105纳米。MPB4.5样品（在锰铁氧体@PB纳米结构中锰铁氧体:PB摩尔比 = 5:4.5）表现出最佳的光热加热效果和良好的光热稳定性，展现出作为光热治疗剂的潜力。所得的锰铁氧体@PB体系为具有磁靶向潜力的肿瘤光热治疗提供了一种精确粒径调控和功能整合的策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/189a/12430317/e11d1fd978c4/nanomaterials-15-01382-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/189a/12430317/720471447f64/nanomaterials-15-01382-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/189a/12430317/4fa51f53686d/nanomaterials-15-01382-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/189a/12430317/241d12803a10/nanomaterials-15-01382-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/189a/12430317/da161f05d66e/nanomaterials-15-01382-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/189a/12430317/21cfe2669203/nanomaterials-15-01382-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/189a/12430317/6ac5cd90a299/nanomaterials-15-01382-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/189a/12430317/06a1aef41d4e/nanomaterials-15-01382-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/189a/12430317/ff51f86cc02f/nanomaterials-15-01382-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/189a/12430317/eec62ad061cb/nanomaterials-15-01382-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/189a/12430317/e11d1fd978c4/nanomaterials-15-01382-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/189a/12430317/720471447f64/nanomaterials-15-01382-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/189a/12430317/9688a4566a20/nanomaterials-15-01382-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/189a/12430317/129dcbc34ad9/nanomaterials-15-01382-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/189a/12430317/4fa51f53686d/nanomaterials-15-01382-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/189a/12430317/241d12803a10/nanomaterials-15-01382-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/189a/12430317/da161f05d66e/nanomaterials-15-01382-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/189a/12430317/21cfe2669203/nanomaterials-15-01382-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/189a/12430317/6ac5cd90a299/nanomaterials-15-01382-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/189a/12430317/06a1aef41d4e/nanomaterials-15-01382-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/189a/12430317/ff51f86cc02f/nanomaterials-15-01382-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/189a/12430317/eec62ad061cb/nanomaterials-15-01382-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/189a/12430317/e11d1fd978c4/nanomaterials-15-01382-g012.jpg

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