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体外集落形成试验中丝裂霉素C暴露量的变化。

Variations in exposure to mitomycin C in an in vitro colony-forming assay.

作者信息

Slee P H, de Bruijn E A, Leeflang P, Kuppen P J, van den Berg L, van Oosterom A T

出版信息

Br J Cancer. 1986 Dec;54(6):951-5. doi: 10.1038/bjc.1986.266.

DOI:10.1038/bjc.1986.266
PMID:3099819
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2001588/
Abstract

The effect of mitomycin C on two human ovarian cancer cell lines was measured during several exposure times and concentrations using the Human Tumour Colony-forming Assay (HTCA). Changes in exposure time and concentration resulted in considerable differences in tumour cell survival. It is concluded that several exposure times and concentrations are necessary for in vitro sensitivity testing. We suggest alternative criteria derived from pharmacokinetic data in patients instead of one-tenth of the peak plasma level which is the usual practice.

摘要

使用人肿瘤集落形成试验（HTCA）在多个暴露时间和浓度下测量了丝裂霉素C对两种人卵巢癌细胞系的作用。暴露时间和浓度的变化导致肿瘤细胞存活率存在显著差异。得出的结论是，体外敏感性测试需要多个暴露时间和浓度。我们建议从患者的药代动力学数据得出替代标准，而不是采用通常的做法即峰值血浆水平的十分之一。

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High mitomycin C concentration in tumour tissue can be achieved by isolated liver perfusion in rats.通过对大鼠进行离体肝脏灌注可使肿瘤组织中丝裂霉素C达到高浓度。
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本文引用的文献

1
In vitro chemosensitivity tests on xenografted human melanomas.人黑色素瘤异种移植瘤的体外化学敏感性试验
Br J Cancer. 1980 Feb;41(2):189-98. doi: 10.1038/bjc.1980.29.
2
Pharmacologic studies of anticancer drugs with the human tumor stem cell assay.采用人肿瘤干细胞检测法对抗癌药物进行的药理学研究。
Cancer Chemother Pharmacol. 1981;6(3):253-64. doi: 10.1007/BF00256978.
3
The application of statistical moment theory to the evaluation of in vivo dissolution time and absorption time.统计矩理论在体内溶出时间和吸收时间评估中的应用。
J Pharmacokinet Biopharm. 1980 Oct;8(5):509-34. doi: 10.1007/BF01059549.
4
Association between human tumor colony-forming assay results and response of an individual patient's tumor to chemotherapy.人类肿瘤集落形成试验结果与个体患者肿瘤对化疗反应之间的关联。
Am J Med. 1981 May;70(5):1027-41. doi: 10.1016/0002-9343(81)90859-7.
5
Time- and concentration-dependent inhibition of the clonogenic growth of N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide-induced murine bladder tumor cell lines by cis-diamminedichloroplatinum(II).顺二氯二氨合铂（II）对N-[4-（5-硝基-2-呋喃基）-2-噻唑基]甲酰胺诱导的小鼠膀胱肿瘤细胞系克隆生长的时间和浓度依赖性抑制作用
Cancer Res. 1982 Mar;42(3):807-11.
6
Time-dose relationships for 5-fluorouracil cytotoxicity against human epithelial cancer cells in vitro.5-氟尿嘧啶对人上皮癌细胞体外细胞毒性的时间-剂量关系。
Cancer Res. 1982 Nov;42(11):4413-20.
7
Pharmacokinetics of the cytostatic drugs used in the CMF-regimen.CMF方案中使用的细胞毒性药物的药代动力学。
Anticancer Res. 1983 Jul-Aug;3(4):269-71.
8
Concentration and time-dependent inter-relationships for antitumour drug cytotoxicities against tumour cells in vitro.体外抗肿瘤药物对肿瘤细胞的细胞毒性的浓度和时间依赖性相互关系。
Int J Cancer. 1983 Jul 15;32(1):7-12. doi: 10.1002/ijc.2910320103.
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An intercomparison of in vitro assays for assessing cytotoxicity after a 24 hour exposure to anti-cancer drugs.用于评估抗癌药物暴露24小时后细胞毒性的体外试验的相互比较。
Tumori. 1983 Feb 28;69(1):37-42. doi: 10.1177/030089168306900106.
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Cancer Res. 1983 Oct;43(10):5017-21.