体外集落形成试验中丝裂霉素C暴露量的变化。
Variations in exposure to mitomycin C in an in vitro colony-forming assay.
作者信息
Slee P H, de Bruijn E A, Leeflang P, Kuppen P J, van den Berg L, van Oosterom A T
出版信息
Br J Cancer. 1986 Dec;54(6):951-5. doi: 10.1038/bjc.1986.266.
Abstract
The effect of mitomycin C on two human ovarian cancer cell lines was measured during several exposure times and concentrations using the Human Tumour Colony-forming Assay (HTCA). Changes in exposure time and concentration resulted in considerable differences in tumour cell survival. It is concluded that several exposure times and concentrations are necessary for in vitro sensitivity testing. We suggest alternative criteria derived from pharmacokinetic data in patients instead of one-tenth of the peak plasma level which is the usual practice.
摘要
使用人肿瘤集落形成试验（HTCA）在多个暴露时间和浓度下测量了丝裂霉素C对两种人卵巢癌细胞系的作用。暴露时间和浓度的变化导致肿瘤细胞存活率存在显著差异。得出的结论是，体外敏感性测试需要多个暴露时间和浓度。我们建议从患者的药代动力学数据得出替代标准，而不是采用通常的做法即峰值血浆水平的十分之一。
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