Long Han, Xu Kunhua, Chen Shanshan, Lin Jin, Wu Dan, Wu Bo, Tian Xu, Ackermann Lutz
Key Laboratory of Molecular Target & Clinical Pharmacology and the State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences & the Fifth Affiliated Hospital , Guangzhou Medical University , Guangzhou , Guangdong 511436 , China.
Institut für Organische und Biomolekulare Chemie , Georg-August-Universität , Tammannstraße 2 , 37077 Göttingen , Germany.
Org Lett. 2019 May 3;21(9):3053-3056. doi: 10.1021/acs.orglett.9b00600. Epub 2019 Apr 18.
An efficient nickel-catalyzed intramolecular direct arylation of imines with challenging aryl chlorides has been developed. The versatile nickel catalysis made use of easily accessible imines and delivered diversely decorated 2-arylindoles of considerable importance to biological and medicinal chemistry.
已开发出一种高效的镍催化亚胺与具有挑战性的芳基氯的分子内直接芳基化反应。这种通用的镍催化反应利用了易于获得的亚胺，并生成了对生物和药物化学具有重要意义的多种修饰的2-芳基吲哚。
