人工智能在 ADME/Tox 中的机遇与挑战。
Opportunities and challenges using artificial intelligence in ADME/Tox.
机构信息
Novartis Institutes for Biomedical Research, Cambridge, MA, USA.
Relay Therapeutics, Cambridge, MA, USA.
出版信息
Nat Mater. 2019 May;18(5):418-422. doi: 10.1038/s41563-019-0332-5.
Abstract
A recent conference organized a panel of scientists representing small and big pharma companies, who work at the interface of machine learning (ML) and absorption, distribution, metabolism, excretion, and toxicology (ADME/Tox). With the recent rebirth of AI related to pharma, it is timely to present this collaborative commentary to capture the diverging opinions on the past, present and future role of AI for ADME/Tox and how it can be applied in newer areas such as nanomaterials.
摘要
最近的一次会议组织了一个由来自小型和大型制药公司的科学家组成的小组，他们在机器学习 (ML) 和吸收、分布、代谢、排泄和毒理学 (ADME/Tox) 的界面上工作。随着与制药相关的人工智能的最新复兴，及时提出这篇合作评论，以捕捉人们对过去、现在和未来人工智能在 ADME/Tox 中的作用的不同看法，以及它如何在纳米材料等新领域得到应用。
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