Zhao Wei, Chu Shanshan, Jiao Yongqing
Collaborative Innovation Center of Henan Grain Crops, College of Agronomy, Henan Agricultural University, Zhengzhou, China.
Key Laboratory of Biology and Genetic Improvement of Oil Crops, Ministry of Agriculture, Oil Crops Research Institute, Chinese Academy of Agricultural Sciences, Wuhan, China.
Front Plant Sci. 2019 Apr 2;10:379. doi: 10.3389/fpls.2019.00379. eCollection 2019.
Circular RNAs (circRNAs) are new endogenous non-coding RNA family members that arise during pre-mRNA splicing in a reversed order in which the 3' and 5' ends are covalently closed. Compared to the comprehensive investigation of circRNAs in animals, circRNA research in plants is still in its infancy. Genome-wide identification and characterization of circRNAs have recently been performed in several plant species. CircRNAs are ubiquitously expressed and abundant in plants. The expression of circRNAs is often dependent on cell-type, tissue, and developmental stage, and it is particularly stress-inducible in plants. CircRNAs might play important roles in various biological processes in plants, including development and the response to biotic and abiotic stresses. Here, we review the current literature and provide a brief overview of circRNAs and their research status in plants, as well as the bioinformatic tools and database resources for circRNA analysis.
环状RNA（circRNAs）是新发现的内源性非编码RNA家族成员，在mRNA前体剪接过程中以相反的顺序产生，其3'和5'末端共价闭合。与动物中对circRNAs的全面研究相比，植物中的circRNA研究仍处于起步阶段。最近在几种植物物种中进行了circRNAs的全基因组鉴定和表征。circRNAs在植物中广泛表达且含量丰富。circRNAs的表达通常依赖于细胞类型、组织和发育阶段，并且在植物中特别受胁迫诱导。circRNAs可能在植物的各种生物学过程中发挥重要作用，包括发育以及对生物和非生物胁迫的响应。在此，我们综述了当前的文献，并简要概述了circRNAs及其在植物中的研究现状，以及用于circRNA分析的生物信息学工具和数据库资源。
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