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Myocardial ischemia: lack of coronary blood flow, myocardial oxygen supply-demand imbalance, or what?心肌缺血：是冠状动脉血流缺乏、心肌氧供需失衡，还是其他原因？
Am J Physiol Heart Circ Physiol. 2019 Jun 1;316(6):H1439-H1446. doi: 10.1152/ajpheart.00139.2019. Epub 2019 Apr 19.
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[Hibernation, stunning, ischemic preconditioning--new paradigms in coronary disease?].[冬眠、心肌顿抑、缺血预处理——冠心病的新范例？]
Z Kardiol. 1992 Nov;81(11):596-609.
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Gradual onset of myocardial ischemia results in reduced myocardial infarction. Association with reduced contractile function and metabolic downregulation.心肌缺血的逐渐发生会导致心肌梗死减少。与收缩功能降低和代谢下调有关。
Circulation. 1995 Apr 1;91(7):2058-70. doi: 10.1161/01.cir.91.7.2058.
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The role of heart rate in myocardial ischemia and infarction: implications of myocardial perfusion-contraction matching.心率在心肌缺血和梗死中的作用：心肌灌注-收缩匹配的意义。
Prog Cardiovasc Dis. 1993 Jul-Aug;36(1):61-74. doi: 10.1016/0033-0620(93)90022-6.
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Myocardial Ischemia: Lack of Coronary Blood Flow or Myocardial Oxygen Supply/Demand Imbalance?心肌缺血：是冠状动脉血流不足还是心肌供需失衡？
Circ Res. 2016 Jul 8;119(2):194-6. doi: 10.1161/CIRCRESAHA.116.308925.
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[Pathophysiology of ischemic myocardial dysfunction].[缺血性心肌功能障碍的病理生理学]
Schweiz Med Wochenschr. 1996 Sep 28;126(39):1654-60.
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The biology of myocardial hibernation.心肌冬眠的生物学
Trends Cardiovasc Med. 2000 Apr;10(3):108-14. doi: 10.1016/s1050-1738(00)00058-x.
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Regional blood flow and contractile function: are they matched in normal, ischemic and reperfused myocardium?局部血流与收缩功能：在正常、缺血及再灌注心肌中它们是否匹配？
Basic Res Cardiol. 1993;88 Suppl 2:103-19.
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The regional myocardial flow-function relationship: a framework for an understanding of acute ischemia, hibernation, stunning and coronary microembolization. 1980.局部心肌血流-功能关系：理解急性缺血、心肌冬眠、心肌顿抑及冠状动脉微栓塞的框架。1980年。
Circ Res. 2013 Jun 7;112(12):1535-7. doi: 10.1161/CIRCRESAHA.113.301446.
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[Pathophysiology of myocardial ischemia].[心肌缺血的病理生理学]
Klin Anasthesiol Intensivther. 1995;47:3-45.
引用本文的文献
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Cardioprotection Reloaded: Reflections on 40 Years of Research.心脏保护重装上阵：40年研究回顾
Antioxidants (Basel). 2025 Jul 18;14(7):889. doi: 10.3390/antiox14070889.
2
Potassium as an electro-metabolic signal for local coronary vasodilation.钾作为局部冠状动脉血管舒张的电代谢信号。
Basic Res Cardiol. 2025 Jun 25. doi: 10.1007/s00395-025-01126-9.
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Specialized Pro-Resolving Mediators as Emerging Players in Cardioprotection: From Inflammation Resolution to Therapeutic Potential.作为心脏保护新角色的特殊促消退介质：从炎症消退到治疗潜力
Acta Physiol (Oxf). 2025 Jul;241(7):e70062. doi: 10.1111/apha.70062.
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A new mechanism of high-altitude adaptation reducing myocardium infarction: inhibiting inflammation-induced ubiquitin degradation of BK to enhance coronary vasodilation.一种减少心肌梗死的高原适应新机制：抑制炎症诱导的BK泛素化降解以增强冠状动脉舒张。
Basic Res Cardiol. 2025 May 7. doi: 10.1007/s00395-025-01113-0.
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Reperfused Myocardial Infarction: The Road to CCS Classification of Acute MI and Beyond.再灌注性心肌梗死：急性心肌梗死及其他情况的CCS分类之路。
JACC Adv. 2025 Feb;4(2):101528. doi: 10.1016/j.jacadv.2024.101528.
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Independent influence of type 2 diabetes on reduced cardiopulmonary fitness in patients after percutaneous coronary intervention: a cross-sectional study.2型糖尿病对经皮冠状动脉介入治疗术后患者心肺适能降低的独立影响：一项横断面研究
Sci Rep. 2025 Feb 19;15(1):6071. doi: 10.1038/s41598-025-90281-z.
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Analytical Insights into Methods for Measuring Ischemia-Modified Albumin.缺血修饰白蛋白测定方法的分析见解。
Molecules. 2024 Sep 29;29(19):4636. doi: 10.3390/molecules29194636.
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Unraveling the Gordian knot of coronary pressure-flow autoregulation.解开冠状动脉压力-血流自动调节的戈尔迪之结。
J Mol Cell Cardiol. 2024 May;190:82-91. doi: 10.1016/j.yjmcc.2024.04.008. Epub 2024 Apr 11.
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Aloperine Alleviates Myocardial Injury Induced by Myocardial Ischemia and Reperfusion by Activating the ERK1/2/β-catenin Signaling Pathway.刺槐碱通过激活ERK1/2/β-连环蛋白信号通路减轻心肌缺血再灌注诱导的心肌损伤。
Cardiovasc Drugs Ther. 2025 Jun;39(3):533-551. doi: 10.1007/s10557-024-07566-0. Epub 2024 Feb 28.
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High Resting Coronary Flow Velocity by Echocardiography Is Associated With Worse Survival in Patients With Chronic Coronary Syndromes.超声心动图显示静息冠脉血流速度高与慢性冠脉综合征患者较差的生存率相关。
J Am Heart Assoc. 2024 Feb 20;13(4):e031270. doi: 10.1161/JAHA.123.031270. Epub 2024 Feb 16.
本文引用的文献
1
Early intravenous beta-blockers in patients undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction: A patient-pooled meta-analysis of randomized clinical trials.ST段抬高型心肌梗死患者接受直接经皮冠状动脉介入治疗时早期静脉注射β受体阻滞剂：一项随机临床试验的患者汇总荟萃分析。
Eur Heart J Acute Cardiovasc Care. 2020 Aug;9(5):469-477. doi: 10.1177/2048872619830609. Epub 2019 Feb 14.
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Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980-2017: a systematic analysis for the Global Burden of Disease Study 2017.全球、区域和国家按年龄、性别和死因分类的死亡率，195 个国家和地区，1980-2017 年：2017 年全球疾病负担研究的系统分析。
Lancet. 2018 Nov 10;392(10159):1736-1788. doi: 10.1016/S0140-6736(18)32203-7. Epub 2018 Nov 8.
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The coronary circulation in acute myocardial ischaemia/reperfusion injury: a target for cardioprotection.在急性心肌缺血/再灌注损伤中的冠状循环：心脏保护的靶点。
Cardiovasc Res. 2019 Jun 1;115(7):1143-1155. doi: 10.1093/cvr/cvy286.
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Practical guidelines for rigor and reproducibility in preclinical and clinical studies on cardioprotection.心脏保护临床前和临床研究中严谨性与可重复性的实用指南。
Basic Res Cardiol. 2018 Aug 17;113(5):39. doi: 10.1007/s00395-018-0696-8.
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Coronary microembolization and microvascular dysfunction.冠状动脉微栓塞与微血管功能障碍。
Int J Cardiol. 2018 May 1;258:17-23. doi: 10.1016/j.ijcard.2018.02.010. Epub 2018 Feb 3.
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Guidelines for experimental models of myocardial ischemia and infarction.心肌缺血和梗死实验模型指南。
Am J Physiol Heart Circ Physiol. 2018 Apr 1;314(4):H812-H838. doi: 10.1152/ajpheart.00335.2017. Epub 2018 Jan 12.
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International standardization of diagnostic criteria for microvascular angina.微血管性心绞痛诊断标准的国际化。
Int J Cardiol. 2018 Jan 1;250:16-20. doi: 10.1016/j.ijcard.2017.08.068. Epub 2017 Sep 8.
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Brief Myocardial Ischemia Produces Cardiac Troponin I Release and Focal Myocyte Apoptosis in the Absence of Pathological Infarction in Swine.短暂性心肌缺血可导致猪在无病理性梗死的情况下出现心肌肌钙蛋白I释放和局灶性心肌细胞凋亡。
JACC Basic Transl Sci. 2017 Apr;2(2):105-114. doi: 10.1016/j.jacbts.2017.01.006. Epub 2017 Mar 29.
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There Is More to β-Blockade Than Just Blockade of β-Receptors: A Case for Cardioprotective Cross-Signaling.β受体阻滞剂的作用远不止于阻断β受体：心脏保护交叉信号传导的实例
J Am Coll Cardiol. 2017 Jul 11;70(2):193-195. doi: 10.1016/j.jacc.2017.05.017.
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Neutrophil stunning by metoprolol reduces infarct size.美托洛尔使中性粒细胞“失活”，减少梗死面积。
Nat Commun. 2017 Apr 18;8:14780. doi: 10.1038/ncomms14780.
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