Department of Radiotherapy, The third People's Hospital of Linyi, Shandong, China.
Department of Radiology, The third People's Hospital of Linyi, Shandong, China.
J Photochem Photobiol B. 2019 May;194:188-193. doi: 10.1016/j.jphotobiol.2019.03.014. Epub 2019 Mar 22.
Theranostic agents were drawing a huge attention in the personalized medication. In this study, we established a facile technique, plant extract-based technique for the synthesis of reduced nano-graphene oxide (RNGO) with low cytotoxicity. We formed platforms of photothermal (PT) therapy and further explained that the synthesized RNGO can be utilized as ready to use PT therapy without any additional surface adjustment. In the meantime, with the help of a constant-wave NIR laser (near-infrared), in vitro esophageal adenocarcinoma cell line (OE-19) cancer cells were effectively ablated, because of the PT impact of RNGO. The outcomes propose that the RNGO was appropriate for PT therapy and photoacoustic imaging of the tumor, which is assuring for theranostic nanomedicine.
治疗诊断试剂在个性化药物治疗中受到了广泛关注。在这项研究中，我们建立了一种简便的技术，基于植物提取物的方法来合成具有低细胞毒性的还原纳米氧化石墨烯（RNGO）。我们构建了光热（PT）治疗平台，并进一步解释说，所合成的 RNGO 可以用作现成的 PT 治疗，而无需进行任何额外的表面调整。同时，借助连续波近红外激光，体外食管腺癌细胞系（OE-19）癌细胞被有效消融，这是由于 RNGO 的 PT 作用。结果表明，RNGO 适用于肿瘤的 PT 治疗和光声成像，这为治疗诊断纳米医学提供了保证。
