Research Center of Siyuan Natural Pharmacy and Biotoxicology, College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang Province 310058, China.
Research Center of Siyuan Natural Pharmacy and Biotoxicology, College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang Province 310058, China.
J Chromatogr A. 2019 Aug 2;1598:1-19. doi: 10.1016/j.chroma.2019.03.046. Epub 2019 Mar 30.
Room ionic liquids (ILs) used as green solvents have received considerable attention and wide application in different research and industrial fields, such as chemistry, biology, catalysis, energy, and even environmental sciences. Recently, a new class of sustainable solvents named deep eutectic solvents (DESs) have been developed, which share the promising solvent characteristics of ILs, such as thermal and chemical stability, low vapor pressure and design ability. In addition, the major advantages of DESs over ILs are their lower prices and easier preparation. Therefore, DESs have been considered to be a potential alternative to replace conventional organic solvents and ILs. Currently, the developed DESs may be classified into ionic and nonionic liquids. Typically, choline chloride (ChCl)/urea (1:2) is an ionic DES, while glucose/sucrose (1:1) is a nonionic DES. Although several reviews have covered advancements in DESs, in this review, we aim to provide a general insight into DESs, particularly ionic DESs, like choline-based DES, in terms of their preparation and application in the extraction of natural products (NPs) mainly from traditional Chinese medicines and the recovery of extracted compounds from their extracts. Additionally, various factors affecting the extraction efficiency of DESs are discussed.
Room 离子液体（ILs）作为绿色溶剂在不同的研究和工业领域，如化学、生物学、催化、能源，甚至环境科学中受到了相当多的关注和广泛应用。最近，一类新型的可持续溶剂被开发出来，称为深共熔溶剂（DESs），它们具有 ILs 的有前途的溶剂特性，如热稳定性和化学稳定性、低蒸气压和设计能力。此外，DESs 相对于 ILs 的主要优点是价格更低、制备更容易。因此，DESs 被认为是替代传统有机溶剂和 ILs 的潜在选择。目前，开发的 DESs 可分为离子型和非离子型。通常，氯化胆碱（ChCl）/尿素（1:2）是一种离子 DES，而葡萄糖/蔗糖（1:1）是非离子 DES。尽管已经有几篇综述涵盖了 DESs 的进展，但在这篇综述中，我们旨在提供对 DESs 的一般了解，特别是基于胆碱的 DESs，如胆碱基 DESs，在从传统中药中提取天然产物（NPs）和从提取物中回收提取化合物方面的制备和应用。此外，还讨论了影响 DESs 提取效率的各种因素。
