Department of Obstetrics and Gynaecology, University of Helsinki and Helsinki University Hospital, FI-00029 Helsinki, Finland.
Best Pract Res Clin Endocrinol Metab. 2019 Feb;33(1):77-88. doi: 10.1016/j.beem.2019.04.001. Epub 2019 Apr 13.
Multiple pregnancies with higher risk of preterm birth and the associated higher morbidity have been a major obstacle from the early days of in vitro fertilization. A good strategy to avoid multiple pregnancies is elective single embryo transfer and cryopreservation of spare embryos. Important factors in adopting this strategy are good counselling of the patients and the selection of embryos with high implantation potential. Technical advances in embryo selection have been described during recent years, time lapse monitoring and genetic assessment of the embryos being the most important achievements. With these studies we have gained new information on early embryos. However, at present, there is insufficient evidence to recommend the routine use of these new techniques. The ultimate goal of infertility treatment is a healthy baby.
多胎妊娠会增加早产风险，相关的高发病率一直是体外受精早期的主要障碍。避免多胎妊娠的一个好策略是选择性单胚胎移植和多余胚胎的冷冻保存。采用这种策略的重要因素是对患者进行良好的咨询和选择具有高着床潜力的胚胎。近年来，胚胎选择技术取得了重要进展，胚胎延时监测和遗传评估是最重要的成果。通过这些研究，我们对早期胚胎有了新的认识。然而，目前尚无足够证据推荐常规使用这些新技术。不孕症治疗的最终目标是生育健康的婴儿。
