a NanoBioCel Group, Laboratory of Pharmaceutics, School of Pharmacy , University of the Basque Country UPV/EHU, Paseo de la Universidad 7 , Vitoria-Gasteiz , Spain.
b Biomedical Research Networking Centre in Bioengineering , Biomaterials and Nanomedicine (CIBER-BBN) , Vitoria-Gasteiz , Spain.
Expert Opin Biol Ther. 2019 Aug;19(8):773-779. doi: 10.1080/14712598.2019.1610383. Epub 2019 May 7.
Biomaterials have provided a wide range of exciting opportunities in tissue engineering and regenerative medicine. Gelatin, a collagen-derived natural biopolymer, has been extensively used in regenerative medicine applications over the years, due to its cell-responsive properties and the capacity to deliver a wide range of biomolecules.
The most relevant properties of gelatin as biomaterial are presented together with its main therapeutic applications. The latter includes drug delivery systems, tissue engineering approaches, potential uses as ink for 3D/4D Bioprinting, and its relevance in organ-on-a-chip platforms.
Advances in polymer chemistry, mechanobiology, imaging technologies, and 3D biofabrication techniques have expanded the application of gelatin in multiple biomedical research applications ranging from bone and cartilage tissue engineering, to wound healing and anti-cancer therapy. Here, we highlight the latest advances in gelatin-based approaches within the fields of biomaterial-based drug delivery and tissue engineering together with some of the most relevant challenges and limitations.
生物材料在组织工程和再生医学领域提供了广泛的令人兴奋的机会。明胶是一种源自胶原蛋白的天然生物聚合物，由于其对细胞的响应特性和能够输送多种生物分子的能力，近年来在再生医学应用中得到了广泛的应用。
本文介绍了明胶作为生物材料的最相关特性及其主要治疗应用。后者包括药物输送系统、组织工程方法、作为 3D/4D 生物打印墨水的潜在用途，以及在器官芯片平台中的相关性。
聚合物化学、机械生物学、成像技术和 3D 生物制造技术的进步扩展了明胶在多种生物医学研究应用中的应用，从骨和软骨组织工程到伤口愈合和抗癌治疗。在这里，我们强调了基于明胶的方法在基于生物材料的药物输送和组织工程领域的最新进展，以及一些最相关的挑战和局限性。
