免疫介导的炎症性疾病相对于银屑病诊断的出现时间顺序。
Chronologic order of appearance of immune-mediated inflammatory diseases relative to diagnosis of psoriasis.
机构信息
Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Dermatology Research and Education Foundation, Irvine, California.
出版信息
J Am Acad Dermatol. 2019 Dec;81(6):1283-1291. doi: 10.1016/j.jaad.2019.04.033. Epub 2019 Apr 19.
BACKGROUND
Psoriasis is a common inflammatory skin disease associated with several immune-mediated inflammatory diseases (IMIDs); however, little is known of the chronology of disease development.
OBJECTIVE
To investigate the chronology of IMIDs relative to psoriasis.
METHODS
We utilized routinely collected data from Danish nationwide administrative registries to examine the occurrence of IMIDs in patients with psoriasis (n = 10,923) and general population controls (n = 109,230).
RESULTS
Approximately 20% of patients with psoriasis developed ≥1 IMID, with a 5-fold increased risk compared with the general population. Most IMIDs were diagnosed before psoriasis, except for psoriatic arthritis. Psoriasis was significantly associated with having multiple IMIDs (odds ratio 15.2, 95% confidence interval 11.6-20.0). Human leukocyte antigen B27 positivity was significantly more frequent among psoriasis patients.
LIMITATIONS
Clinical measurements were unavailable.
CONCLUSION
IMIDs occur frequently in patients with psoriasis and most are diagnosed before psoriasis. The observed chronology might represent important mechanisms of disease development.
背景
银屑病是一种常见的炎症性皮肤病，与几种免疫介导的炎症性疾病（IMIDs）有关；然而，对于疾病发展的时间顺序知之甚少。
目的
研究相对于银屑病的 IMIDs 的发病时间顺序。
方法
我们利用丹麦全国性行政登记处的常规收集数据，检查银屑病患者（n=10923）和一般人群对照者（n=109230）中 IMIDs 的发生情况。
结果
约 20%的银屑病患者出现≥1 种 IMID，与一般人群相比，风险增加了 5 倍。除了银屑病关节炎外，大多数 IMIDs 的诊断时间都早于银屑病。银屑病与多种 IMIDs 显著相关（优势比 15.2，95%置信区间 11.6-20.0）。银屑病患者的人类白细胞抗原 B27 阳性率显著更高。
局限性
缺乏临床测量。
结论
IMIDs 在银屑病患者中频繁发生，且大多数在银屑病之前被诊断。观察到的发病时间顺序可能代表疾病发展的重要机制。
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