Dybowska-Gołota Izabela, Owczarczyk-Saczonek Agnieszka, Krajewska-Włodarczyk Magdalena, Żuber Zbigniew
4 Department of Pediatric Rheumatology and Endocrinology, Regional Specialized Children's Hospital in Olsztyn, Poland.
Department and Clinic of Dermatology, Sexually Transmitted Diseases and Clinical Immunology, University of Warmia and Mazury, Olsztyn, Poland.
Reumatologia. 2020;58(1):48-55. doi: 10.5114/reum.2020.93516. Epub 2020 Feb 28.
Immune-mediated inflammatory diseases are a group of diseases characterized by generalized inflammation that results from immune dysregulation, especially involving the mechanisms of acquired immunity. These diseases may be familial, showing that genetic factors play an important role in their development. Additionally, the occurrence of one disease makes a patient prone to other diseases. However, the coexistence of systemic lupus erythematosus (SLE) and psoriasis (Ps) is very rare due to their distinct genetic determinants and mechanisms of pathogenesis. Treatment is also challenging, as medications used to treat one condition exacerbate or even trigger the symptoms of the other. This paper presents the case of a Ps patient with a family history of autoimmune diseases, who developed systemic lupus erythematosus during puberty, as well as a discussion on the coexistence of SLE and Ps in developmental age based on available literature searching for PubMed database and American College of Rheumatology and European League Against Rheumatism abstracts particularly in this subject.
免疫介导的炎症性疾病是一组以全身炎症为特征的疾病，这种炎症是由免疫失调引起的，尤其涉及获得性免疫机制。这些疾病可能具有家族性，表明遗传因素在其发病过程中起重要作用。此外，患有一种疾病会使患者更容易患上其他疾病。然而，系统性红斑狼疮（SLE）和银屑病（Ps）由于其独特的遗传决定因素和发病机制，同时存在的情况非常罕见。治疗也具有挑战性，因为用于治疗一种疾病的药物会加重甚至引发另一种疾病的症状。本文介绍了一名有自身免疫性疾病家族史的银屑病患者，该患者在青春期患上了系统性红斑狼疮，并基于在PubMed数据库以及美国风湿病学会和欧洲抗风湿病联盟摘要中进行的文献检索，特别是关于这一主题的文献，对发育年龄阶段SLE和Ps的共存情况进行了讨论。
