Li Zhenzhuo, Jiang Rui, Liu Jianzeng, Xu Xiaohao, Sun Liwei, Zhao Daqing
Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun, Jilin 130117, China.
Research Center of Traditional Chinese Medicine, The Affiliated Hospital to Changchun University of Chinese Medicine, Changchun, Jilin 130021, China.
Evid Based Complement Alternat Med. 2021 Aug 2;2021:9962007. doi: 10.1155/2021/9962007. eCollection 2021.
Here, we evaluated the skin-protective effects of topical applications of C. A. Meyer extract (PG2) and its phenolic acid- (PA-) based components against UVB-induced skin photoaging. PG2 or PA applied to skin of hairless mice after UVB-irradiation alleviated UVB-induced effects observed in untreated skin, such as increased transepidermal water loss (TEWL), increased epidermal thickness, and decreased stratum corneum water content without affecting body weight. Moreover, PG2 and PA treatments countered reduced mRNA-level expression of genes encoding filaggrin (FLG), transglutaminase-1 (TGM1), and hyaluronan synthases (HAS1, HAS2, and HAS3) caused by UVB exposure and reduced UVB-induced collagen fiber degradation by inhibiting the expression of matrix metalloproteinase genes encoding MMP-1, MMP-2, and MMP-9. Meanwhile, topical treatments reduced cyclooxygenase-2 (COX-2) mRNA-level expression in photodamaged skin, leading to the inhibition of interleukin-1 (IL-1) and interleukin-6 (IL-6) mRNA-level expression. Thus, ginseng phenolic acid-based preparations have potential value as topical treatments to protect skin against UVB-induced photoaging.
在此，我们评估了人参提取物（PG2）及其酚酸类成分局部应用对紫外线B（UVB）诱导的皮肤光老化的皮肤保护作用。UVB照射后将PG2或酚酸类成分涂抹于无毛小鼠皮肤上，可减轻未处理皮肤中观察到的UVB诱导的效应，如经表皮水分流失（TEWL）增加、表皮厚度增加和角质层含水量降低，且不影响体重。此外，PG2和酚酸类成分处理可对抗UVB暴露导致的编码兜甲蛋白（FLG）、转谷氨酰胺酶-1（TGM1）和透明质酸合成酶（HAS1、HAS2和HAS3）的基因mRNA水平表达降低，并通过抑制编码基质金属蛋白酶-1（MMP-1）、基质金属蛋白酶-2（MMP-2）和基质金属蛋白酶-9（MMP-9）的基因表达来减少UVB诱导的胶原纤维降解。同时，局部处理降低了光损伤皮肤中环氧合酶-2（COX-2）的mRNA水平表达，从而抑制白细胞介素-1（IL-1）和白细胞介素-6（IL-6）的mRNA水平表达。因此，基于人参酚酸的制剂作为局部治疗手段，在保护皮肤免受UVB诱导的光老化方面具有潜在价值。
