MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK; School of Physics and Astronomy, University of Edinburgh, EH9 3FD, UK.
MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.
Curr Opin Cell Biol. 2019 Jun;58:120-125. doi: 10.1016/j.ceb.2019.03.007. Epub 2019 Apr 19.
The importance of three-dimensional chromatin organisation in genome regulation has never been clearer. But in spite of the enormous technological advances to probe chromatin organisation in vivo, there is still a lack of mechanistic understanding of how such an arrangement is achieved. Here we review emerging evidence pointing to an intriguing role of nuclear RNA in shaping large-scale chromatin structure and regulating genome function. We suggest this role may be achieved through the formation of a dynamic nuclear mesh that can exploit ATP-driven processes and phase separation of RNA-binding proteins to tune its assembly and material properties.
三维染色质组织在基因组调控中的重要性再明显不过了。但是，尽管有了探测体内染色质组织的巨大技术进步，但对于这种排列方式是如何实现的，我们仍然缺乏机械上的理解。在这里，我们回顾了一些新出现的证据，这些证据表明核 RNA 在塑造大规模染色质结构和调节基因组功能方面具有有趣的作用。我们认为，这种作用可能是通过形成一个动态的核网格来实现的，该网格可以利用 ATP 驱动的过程和 RNA 结合蛋白的相分离来调节其组装和物质特性。
