Department of Molecular Microbiology, Washington University School of Medicine in St. Louis, St. Louis, MO 63110.
Department of Pathology and Immunology, Washington University School of Medicine in St. Louis, St. Louis, MO 63110; and.
J Immunol. 2019 May 1;202(9):2519-2526. doi: 10.4049/jimmunol.1801135.
Inducible bronchus-associated lymphoid tissue (iBALT) is a tertiary lymphoid structure that resembles secondary lymphoid organs. iBALT is induced in the lung in response to Ag exposure. In some cases, such as infection with , the formation of iBALT structure is indicative of an effective protective immune response. However, with persistent exposure to Ags during chronic inflammation, allergy, or autoimmune diseases, iBALT may be associated with exacerbation of inflammation. iBALT is characterized by well-organized T and B areas enmeshed with conventional dendritic cells, follicular dendritic cells, and stromal cells, usually located surrounding airways or blood vessels. Several of the molecular signals and cellular contributors that mediate formation of iBALT structures have been recently identified. This review will outline the recent findings associated with the formation and maintenance of iBALT and their contributions toward a protective or pathogenic function in pulmonary disease outcome.
诱导性支气管相关淋巴组织 (iBALT) 是一种类似于次级淋巴器官的三级淋巴结构。iBALT 是在肺中对 Ag 暴露作出反应而诱导产生的。在某些情况下，例如感染 ，iBALT 结构的形成表明存在有效的保护性免疫反应。然而，在慢性炎症、过敏或自身免疫性疾病期间持续暴露于 Ag 时，iBALT 可能与炎症加重有关。iBALT 的特征是与常规树突状细胞、滤泡树突状细胞和基质细胞交织在一起的组织良好的 T 和 B 区，通常位于气道或血管周围。最近已经鉴定出介导 iBALT 结构形成的一些分子信号和细胞贡献者。这篇综述将概述与 iBALT 的形成和维持相关的最新发现，以及它们对肺部疾病结果的保护性或致病性功能的贡献。
