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州医疗补助计划扩张状况与低出生体重儿和早产的关联。

Association of State Medicaid Expansion Status With Low Birth Weight and Preterm Birth.

机构信息

Department of Health Policy and Management, University of Arkansas for Medical Sciences, Little Rock.

Institute for Medicaid Innovation, Washington, DC.

出版信息

JAMA. 2019 Apr 23;321(16):1598-1609. doi: 10.1001/jama.2019.3678.

DOI:10.1001/jama.2019.3678
PMID:31012935
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6487545/
Abstract

IMPORTANCE

Low birth weight and preterm birth are associated with adverse consequences including increased risk of infant mortality and chronic health conditions. Black infants are more likely than white infants to be born prematurely, which has been associated with disparities in infant mortality and other chronic conditions.

OBJECTIVE

To evaluate whether Medicaid expansion was associated with changes in rates of low birth weight and preterm birth outcomes, both overall and by race/ethnicity.

DESIGN, SETTING, AND PARTICIPANTS: Using US population-based data from the National Center for Health Statistics Birth Data Files (2011-2016), difference-in-differences (DID) and difference-in-difference-in-differences (DDD) models were estimated using multivariable linear probability regressions to compare birth outcomes among infants in Medicaid expansion states relative to non-Medicaid expansion states and changes in relative disparities among racial/ethnic minorities for singleton live births to women aged 19 years and older.

EXPOSURES

State Medicaid expansion status and racial/ethnic category.

MAIN OUTCOMES AND MEASURES

Preterm birth (<37 weeks' gestation), very preterm birth (<32 weeks' gestation), low birth weight (<2500 g), and very low birth weight (<1500 g).

RESULTS

The final sample of 15 631 174 births (white infants: 8 244 924, black infants: 2 201 658, and Hispanic infants: 3 944 665) came from the District of Columbia and 18 states that expanded Medicaid (n = 8 530 751) and 17 states that did not (n = 7 100 423). In the DID analyses, there were no significant changes in preterm birth in expansion relative to nonexpansion states (preexpansion to postexpansion period, 6.80% to 6.67% [difference: -0.12] vs 7.86% to 7.78% [difference: -0.08]; adjusted DID: 0.00 percentage points [95% CI, -0.14 to 0.15], P = .98), very preterm birth (0.87% to 0.83% [difference: -0.04] vs 1.02% to 1.03% [difference: 0.01]; adjusted DID: -0.02 percentage points [95% CI, -0.05 to 0.02], P = .37), low birth weight (5.41% to 5.36% [difference: -0.05] vs 6.06% to 6.18% [difference: 0.11]; adjusted DID: -0.08 percentage points [95% CI, -0.20 to 0.04], P = .20), or very low birth weight (0.76% to 0.72% [difference: -0.03] vs 0.88% to 0.90% [difference: 0.02]; adjusted DID: -0.03 percentage points [95% CI, -0.06 to 0.01], P = .14). Disparities for black infants relative to white infants in Medicaid expansion states compared with nonexpansion states declined for all 4 outcomes, indicated by a negative DDD coefficient for preterm birth (-0.43 percentage points [95% CI, -0.84 to -0.02], P = .05), very preterm birth (-0.14 percentage points [95% CI, -0.26 to -0.02], P = .03), low birth weight (-0.53 percentage points [95% CI, -0.96 to -0.10], P = .02), and very low birth weight (-0.13 percentage points [95% CI, -0.25 to -0.01], P = .04). There were no changes in relative disparities for Hispanic infants.

CONCLUSIONS AND RELEVANCE

Based on data from 2011-2016, state Medicaid expansion was not significantly associated with differences in rates of low birth weight or preterm birth outcomes overall, although there were significant improvements in relative disparities for black infants compared with white infants in states that expanded Medicaid vs those that did not.

摘要

重要性

低出生体重和早产与不良后果相关,包括婴儿死亡率增加和慢性健康状况。黑人婴儿比白人婴儿更容易早产,这与婴儿死亡率和其他慢性疾病的差异有关。

目的

评估医疗补助计划扩大是否与低出生体重和早产结局的变化相关,包括总体情况和种族/族裔差异。

设计、地点和参与者:利用美国国家卫生统计中心出生数据文件(2011-2016 年)中的人口数据,使用多变量线性概率回归估计差异中的差异(DID)和差异中的差异中的差异(DDD)模型,将医疗补助计划扩大州的单胎活产婴儿的出生结局与非医疗补助计划扩大州进行比较,以及 19 岁及以上妇女的种族/族裔少数民族之间相对差异的变化。

暴露因素

州医疗补助计划扩大状况和种族/族裔类别。

主要结果和测量

早产(<37 周妊娠)、极早产(<32 周妊娠)、低出生体重(<2500 克)和极低出生体重(<1500 克)。

结果

最终样本为 15631740 例出生(白人婴儿:8244924 例,黑人婴儿:2201658 例,西班牙裔婴儿:3944665 例),来自哥伦比亚特区和 18 个扩大医疗补助计划的州(n=8530751)和 17 个没有扩大医疗补助计划的州(n=7100423)。在 DID 分析中,在扩大与非扩大州相比,早产没有显著变化(预扩张期至后扩张期,6.80%至 6.67%[差异:-0.12]vs7.86%至 7.78%[差异:-0.08];调整后的 DID:0.00 个百分点[95%CI,-0.14 至 0.15],P=0.98)、极早产(0.87%至 0.83%[差异:-0.04]vs1.02%至 1.03%[差异:0.01];调整后的 DID:-0.02 个百分点[95%CI,-0.05 至 0.02],P=0.37)、低出生体重(5.41%至 5.36%[差异:-0.05]vs6.06%至 6.18%[差异:0.11];调整后的 DID:-0.08 个百分点[95%CI,-0.20 至 0.04],P=0.20)或极低出生体重(0.76%至 0.72%[差异:-0.03]vs0.88%至 0.90%[差异:0.02];调整后的 DID:-0.03 个百分点[95%CI,-0.06 至 0.01],P=0.14)。与非扩大州相比,在扩大医疗补助计划的州中,黑人婴儿与白人婴儿相比,这 4 项结果的相对差异有所下降,这表明早产(-0.43 个百分点[95%CI,-0.84 至-0.02],P=0.05)、极早产(-0.14 个百分点[95%CI,-0.26 至-0.02],P=0.03)、低出生体重(-0.53 个百分点[95%CI,-0.96 至-0.10],P=0.02)和极低出生体重(-0.13 个百分点[95%CI,-0.25 至-0.01],P=0.04)的 DDD 系数为负。西班牙裔婴儿的相对差异没有变化。

结论和相关性

基于 2011-2016 年的数据,州医疗补助计划扩大与低出生体重或早产结局的总体差异没有显著关联,尽管与未扩大医疗补助计划的州相比,扩大医疗补助计划的州中黑人婴儿与白人婴儿的相对差异有所改善。

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