Department of Pharmacy, Faculty of Pharmacy, Silpakorn University, Nakhon-Pathom, Thailand.
Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand.
PLoS One. 2019 Apr 23;14(4):e0215840. doi: 10.1371/journal.pone.0215840. eCollection 2019.
Studies have demonstrated inconsistent effects of curcumin on glycemic outcomes and lipid parameters in patients with prediabetes and type 2 diabetes mellitus (T2DM). This study aimed to assess the effect of curcumin on glycemic control and lipid profile in prediabetes and T2DM.
A systematic search of randomized controlled trials (RCTs) was conducted from inception to June 2018 in electronic sources including AMED, ANZCTR, BioMed Central, CENTRAL, CINAHL, ClinicalTrials.gov, Expanded Academic Index, Google Scholar, ISRCTN, LILACS, MEDLINE, NCCIH, Science Direct, Scopus, Web of Science, and WHO ICTRP. Hand search was also performed. Of the total 486 records, four trials (N = 508) and eight trials (N = 646) were eligible for the meta-analysis of individuals with prediabetes and T2DM, respectively. Curcumin significantly reduced glycosylated hemoglobin (HbA1c) in prediabetics (MD: -0.9%, 95% CI: -1.7 to -0.1%, p = 0.03). Furthermore, T2DM subjects gained favorable reduction in both HbA1c (MD: -0.5%, 95% CI: -1.0 to -0.0%, p = 0.04) and fasting plasma glucose (MD: -11.7 mg/dL, 95% CI: -22.1 to -1.3 mg/dL, p = 0.03). Tendency of lipid profile improvement was also observed.
Our findings may encourage curcumin supplementation based on its meaningful effect on glycemic control and positive trend on lipid outcomes in prediabetes and T2DM.
研究表明，姜黄素对糖尿病前期和 2 型糖尿病患者的血糖结局和血脂参数的影响不一致。本研究旨在评估姜黄素对糖尿病前期和 2 型糖尿病患者血糖控制和血脂谱的影响。
从研究开始到 2018 年 6 月，在 AMED、ANZCTR、BioMed Central、CENTRAL、CINAHL、ClinicalTrials.gov、Expanded Academic Index、Google Scholar、ISRCTN、LILACS、MEDLINE、NCCIH、Science Direct、Scopus、Web of Science 和 WHO ICTRP 等电子资源中进行了系统的随机对照试验 (RCT) 检索。还进行了手工检索。在总共 486 条记录中，有四项试验（N = 508）和八项试验（N = 646）分别符合对糖尿病前期和 2 型糖尿病患者进行荟萃分析的条件。姜黄素可显著降低糖尿病前期患者的糖化血红蛋白 (HbA1c)（MD：-0.9%，95%CI：-1.7 至-0.1%，p = 0.03）。此外，2 型糖尿病患者的 HbA1c（MD：-0.5%，95%CI：-1.0 至-0.0%，p = 0.04）和空腹血糖（MD：-11.7mg/dL，95%CI：-22.1 至-1.3mg/dL，p = 0.03）均有明显降低。血脂谱改善的趋势也观察到。
我们的发现可能会鼓励基于姜黄素对血糖控制的显著影响以及对糖尿病前期和 2 型糖尿病患者血脂结果的积极趋势的补充。
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