Amini Sepide, Sahebkar Amirhossein, Dehghani Alireza, Iraj Bijan, Rezaeian-Ramsheh Abdolreza, Askari Gholamreza, Majeed Muhammed, Bagherniya Mohammad
Nutrition and Food Security Research Center, Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Avicenna J Phytomed. 2023 Mar-Apr;13(2):153-164. doi: 10.22038/AJP.2022.21512.
Curcumin is a safe phytochemical with antioxidant, anti-inflammatory, antidiabetic, and lipid-lowering effects. This study aims to investigate the efficacy of curcumin-piperine in non-proliferative diabetic retinopathy.
In this double-blind randomized trial, 60 diabetic retinopathy patients after meeting the inclusion criteria will be randomly assigned to two groups of curcumin-piperine supplementation (1000 mg per day for 12 weeks) or receiving placebo. The density of small blood vessels in the retina by optical coherence tomography angiography (OCTA), fasting blood glucose, triglyceride, renal indices (blood urea nitrogen and creatinine), high-sensitivity C-reactive protein, total antioxidant capacity, total oxidant status, body mass index, waist circumference, and weight will be measured.
If the beneficial effects of curcumin on diabetic retinopathy are observed, this safe, this natural and inexpensive herbal supplement can be considered a therapeutic solution in these patients.
姜黄素是一种具有抗氧化、抗炎、抗糖尿病和降脂作用的安全植物化学物质。本研究旨在探讨姜黄素-胡椒碱对非增殖性糖尿病视网膜病变的疗效。
在这项双盲随机试验中，60名符合纳入标准的糖尿病视网膜病变患者将被随机分为两组，一组补充姜黄素-胡椒碱（每天1000毫克，持续12周），另一组接受安慰剂。通过光学相干断层扫描血管造影（OCTA）测量视网膜小血管密度、空腹血糖、甘油三酯、肾脏指标（血尿素氮和肌酐）、高敏C反应蛋白、总抗氧化能力、总氧化状态、体重指数、腰围和体重。
如果观察到姜黄素对糖尿病视网膜病变有有益作用，这种安全、天然且廉价的草药补充剂可被视为这些患者的一种治疗解决方案。
