Institute of Pharmaceutical Technologies, Medical Academy, Lithuanian University of Health Sciences, Sukileliu pr. 13, Kaunas LT-50161, Lithuania.
Department of Drug Technology and Social Pharmacy, Medical Academy, Lithuanian University of Health Sciences, Sukileliu pr. 13, Kaunas LT-50161, Lithuania.
Molecules. 2020 May 9;25(9):2237. doi: 10.3390/molecules25092237.
The present study reports on the encapsulation of ethanolic extract by freeze-drying method using skim milk, sodium caseinate, gum Arabic, maltodextrin, beta-maltodextrin, and resistant-maltodextrin alone or in mixtures of two or four encapsulants. The encapsulation ability of the final mixtures was evaluated based on their microencapsulating efficiency (EE) of total phenolic compounds (TPC) and the physicochemical properties of freeze-dried powders. Results showed that the freeze-dried powders produced using two encapsulants have a lower moisture content, but higher solubility, Carr index, and Hausner ratio than freeze-dried powders produced using only one encapsulant in the formulation. The microencapsulating efficiency of TPC also varied depending on encapsulants used. The lowest EE% of TPC was determined with maltodextrin (21.17%), and the highest with sodium caseinate (83.02%). Scanning electron microscopy revealed that freeze-drying resulted in the formation of different size, irregular shape glassy particles. This study demonstrated good mucoadhesive properties of freeze-dried powders, which could be incorporated in buccal or oral delivery dosage forms. In conclusion, the microencapsulation of ethanolic extract by freeze-drying is an effective method to produce new value-added pharmaceutical or food formulations with polyphenols.
本研究报告了使用脱脂乳、酪蛋白酸钠、阿拉伯胶、麦芽糊精、β-麦芽糊精和抗性麦芽糊精单独或两种或四种包封剂的混合物通过冷冻干燥法对醇提物进行包封的情况。根据总酚化合物（TPC）的微囊化效率（EE）和冷冻干燥粉末的物理化学性质，评估了最终混合物的包封能力。结果表明，与配方中仅使用一种包封剂相比，使用两种包封剂生产的冷冻干燥粉末的水分含量较低，但溶解度、Carr 指数和 Hausner 比高。TPC 的微囊化效率也取决于所用的包封剂。TPC 的最低 EE%是用麦芽糊精（21.17%）确定的，最高的是用酪蛋白酸钠（83.02%）确定的。扫描电子显微镜显示，冷冻干燥导致形成不同大小、不规则形状的玻璃状颗粒。本研究表明，冷冻干燥粉末具有良好的粘膜粘附性能，可用于颊部或口服给药剂型。总之，通过冷冻干燥对醇提物进行微囊化是一种生产具有多酚的新型高附加值药物或食品制剂的有效方法。
