Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, Illinois, USA.
Department of Ophthalmology, University of Southern California, Los Angeles, California, USA.
Acta Ophthalmol. 2019 Nov;97(7):e968-e972. doi: 10.1111/aos.14120. Epub 2019 Apr 24.
To test the hypothesis that visual field (VF) loss is associated with decreased retinal blood flow, oxygen delivery and metabolism, and with increased retinal oxygen extraction fraction (OEF) in glaucomatous individuals.
Glaucomatous subjects underwent automated perimetry, dual wavelength scanning laser ophthalmoscopy and Doppler optical coherence tomography imaging in order to measure mean deviation, central retinal arterial and venous diameter equivalents (CRAE and CRVE), oxygen saturation levels and total retinal blood flow (TRBF), respectively. Retinal oxygen delivery, metabolism and extraction fraction were derived from measurements of oxygen saturation and blood flow.
Twenty eyes of 14 subjects were included in the study. Mean deviation was on average -13.76 ± 8.70 dB. Mean CRAE and CRVE were 126 ± 28 and 191 ± 35 μm, respectively. Mean TRBF and oxygen delivery were 34.3 ± 11.7 μl/min and 6.5 ± 2.6 μl O /min, respectively. Mean oxygen metabolism and extraction fraction were 2.1 ± 0.94 μl O /min and 0.34 ± 0.15, respectively. Visual field (VF) loss was associated with reduced CRAE and CRVE, TRBF and oxygen delivery and associated with increased OEF.
Combined measurements of retinal blood flow and oxygen saturation in glaucomatous individuals suggest VF loss is associated with impaired oxygen delivery and augmented OEF.
验证视野（VF）损失与青光眼患者视网膜血流、氧输送和代谢减少以及视网膜氧提取分数（OEF）增加相关的假说。
对青光眼患者进行自动视野检查、双波长扫描激光检眼镜和多普勒光相干断层扫描成像，以分别测量平均偏差、中央视网膜动脉和静脉直径等效值（CRAE 和 CRVE）、氧饱和度水平和总视网膜血流（TRBF）。视网膜氧输送、代谢和提取分数是通过测量氧饱和度和血流得出的。
本研究纳入了 14 名患者的 20 只眼。平均偏差平均为-13.76±8.70dB。平均 CRAE 和 CRVE 分别为 126±28μm 和 191±35μm。平均 TRBF 和氧输送分别为 34.3±11.7μl/min 和 6.5±2.6μl O/min。平均氧代谢和提取分数分别为 2.1±0.94μl O/min 和 0.34±0.15。VF 损失与 CRAE 和 CRVE、TRBF 和氧输送减少相关，与 OEF 增加相关。
在青光眼患者中联合测量视网膜血流和氧饱和度表明，VF 损失与氧输送受损和 OEF 增加有关。
