Department of Materials Science and Engineering, School of Molecular Science and EngineeringVidyasirimedhi Institute of Science and Technology (VISTEC), Rayong, 21210, Thailand.
Macromol Biosci. 2019 Jun;19(6):e1900063. doi: 10.1002/mabi.201900063. Epub 2019 Apr 24.
Nanoparticles have the advantages over micron-sized particles to typically provide higher intracellular uptake and drug bioavailability. Emulsion techniques are commonly used methods for producing nanoparticles aiming at high encapsulation efficiency, high stability, and low toxicity. Here, the recent developments of nanoparticles prepared from emulsions, the synthesis of nanoparticles, their physicochemical properties, and their biomedical applications are discussed. Selection of techniques, such as emulsion polymerization, miniemulsion polymerization, microemulsion polymerization, and emulsion-solvent evaporation processes, strongly influences morphologies, size distributions, and particle properties. Details in the synthetic strategies governing the performance of nanoparticles in bioimaging, biosensing, and drug delivery are presented. Benefits and limitations of molecular imaging techniques are also discussed.
纳米粒子相对于微米级粒子具有能够提供更高的细胞内摄取和药物生物利用度的优点。乳液技术是常用于制备纳米粒子的方法，目的是实现高包封效率、高稳定性和低毒性。本文讨论了由乳液制备的纳米粒子的最新进展、纳米粒子的合成、其物理化学性质以及它们在生物医学中的应用。技术的选择，如乳液聚合、细乳液聚合、微乳液聚合和乳液-溶剂蒸发过程，强烈影响形态、粒径分布和颗粒性质。详细介绍了控制纳米粒子在生物成像、生物传感和药物输送中性能的合成策略。还讨论了分子成像技术的优点和局限性。
