Piñón-Segundo Elizabeth, Nava-Arzaluz María G, Lechuga-Ballesteros David
Laboratorio de Sistemas de Liberacion Modificada, L-13 UIM, Facultad de Estudios Superiores Cuautitlan, Universidad Nacional Autonoma de Mexico. Km 2.5 Carretera Cuautitlan- Teoloyucan, San Sebastian Xhala, Cuautitlan Izcalli, Estado de Mexico CP. 54714.
Recent Pat Drug Deliv Formul. 2012 Dec;6(3):224-35. doi: 10.2174/187221112802652606.
The most common technique to produce nanoparticles involves evaporation of a polymer emulsion to obtain polymeric particles less than 500 nm in size. And since its introduction in the late 1970's, this process has been widely used for pharmaceutical applications to obtain clinically applicable drug delivery systems. Many adjustments and adaptations of this technique have been made, attempting encapsulation of a wide variety of bioactive compounds. The advantages and drawbacks of the single-emulsion and especially double (multiple)-emulsion techniques are discussed in the present review article. It covers patent and patent applications literature, as well as peer reviewed research papers discussing pharmaceutical polymer-based nanoparticles obtained by the double emulsion-solvent evaporation technique using preformed polymers.
制备纳米颗粒最常用的技术是蒸发聚合物乳液以获得尺寸小于500纳米的聚合物颗粒。自20世纪70年代末引入以来，该工艺已广泛用于制药应用，以获得临床适用的药物递送系统。人们对该技术进行了许多调整和改进，试图封装各种各样的生物活性化合物。本文综述讨论了单乳液尤其是双（多）乳液技术的优缺点。它涵盖了专利和专利申请文献，以及同行评审的研究论文，这些论文讨论了使用预制聚合物通过双乳液-溶剂蒸发技术获得的基于药物聚合物的纳米颗粒。
