Sullivan Luis F
Institute of Neuroscience, University of Oregon, Eugene, OR, United States.
Front Mol Neurosci. 2019 Apr 4;12:82. doi: 10.3389/fnmol.2019.00082. eCollection 2019.
Neurons originate from neural stem cells and then synapse with stereotyped partners to form neuronal circuits. Recent findings indicate that several molecular mechanisms generating neuronal identity can rewire neuronal connectivity in the brain when genetically manipulated. In this review, I discuss how mechanisms generating neuronal identity could activate molecular pathways essential for circuit formation and function. Next, I propose that the central complex of , an ancient and highly conserved brain region essential for locomotor control and navigation, is an excellent model system to further explore mechanisms linking circuit development to circuit function.
神经元起源于神经干细胞，然后与固定的伙伴形成突触以构建神经回路。最近的研究结果表明，在进行基因操作时，几种决定神经元特性的分子机制能够重塑大脑中的神经元连接。在这篇综述中，我将探讨决定神经元特性的机制如何激活对神经回路形成和功能至关重要的分子途径。接下来，我提出，作为一个对运动控制和导航至关重要的古老且高度保守的脑区，其中央复合体是进一步探索将神经回路发育与回路功能联系起来的机制的绝佳模型系统。
